Olfactory bulb microcircuits model with dual-layer inhibition (Gilra & Bhalla 2015)

 Download zip file 
Help downloading and running models
Accession:153574
A detailed network model of the dual-layer dendro-dendritic inhibitory microcircuits in the rat olfactory bulb comprising compartmental mitral, granule and PG cells developed by Aditya Gilra, Upinder S. Bhalla (2015). All cell morphologies and network connections are in NeuroML v1.8.0. PG and granule cell channels and synapses are also in NeuroML v1.8.0. Mitral cell channels and synapses are in native python.
Reference:
1 . Gilra A, Bhalla US (2015) Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding. PLoS One 10:e0098045 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I A; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: Python; MOOSE/PyMOOSE;
Model Concept(s): Sensory processing; Sensory coding; Markov-type model; Olfaction;
Implementer(s): Bhalla, Upinder S [bhalla at ncbs.res.in]; Gilra, Aditya [aditya_gilra -at- yahoo -period- com];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main interneuron granule MC GABA cell; AMPA; NMDA; Gaba; I A; I h; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba; Glutamate;
<?xml version="1.0" encoding="UTF-8"?>
<neuroml xmlns="http://morphml.org/neuroml/schema"
    xmlns:mml="http://morphml.org/morphml/schema"
    xmlns:meta="http://morphml.org/metadata/schema"
    xmlns:bio="http://morphml.org/biophysics/schema"
    xmlns:cml="http://morphml.org/channelml/schema"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xsi:schemaLocation="http://morphml.org/neuroml/schema http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.0/Level3/NeuroML_Level3_v1.8.0.xsd"
    name = "NeuroML Level 1 file exported from NEURON"
    lengthUnits="micron">

<meta:notes>author: Aditya Gilra adapted from Migliore and Shepherd 2007.</meta:notes>

<cells>
  <cell name="granule">
    <meta:notes>Cell: granule morphml written by hand by Aditya.</meta:notes>
    <segments  xmlns="http://morphml.org/morphml/schema"> <!-- Changing the namespace from neuroml to morphml-->
<!-- Section: soma -->
      <segment id="0" name = "soma" cable = "0">
        <proximal x="0" y="0" z="0" diameter="8"/>
        <distal x="0" y="0" z="8" diameter="8"/>
      </segment>
<!-- Section: periphery -->
      <segment id="1" name = "periphery" parent="0" cable = "1">  <!-- Connected at 1 on parent section: soma  -->
        <proximal x="0" y="0" z="8" diameter="0.5"/>
        <distal x="0" y="0" z="158" diameter="0.5"/>
      </segment>
    </segments>
    <cables  xmlns="http://morphml.org/morphml/schema"> <!-- Changing namespace from neuroml to morphml-->
      <cable id = "0" name = "soma" fract_along_parent = "0"/>
      <cable id = "1" name = "periphery" fract_along_parent = "1"/>
      <cablegroup name="all">
        <cable id = "0"/>
        <cable id = "1"/>
      </cablegroup>
      <cablegroup name="soma"> 
        <cable id = "0"/>
      </cablegroup>
      <cablegroup name="periphery"> 
        <cable id = "1"/>
      </cablegroup>
    </cables>
      <biophysics units='Physiological Units'>
        <!-- Note: values of cond dens are different in NEURON and phy units-->
        <bio:mechanism xmlns:bio='http://morphml.org/biophysics/schema' passive_conductance='true' type='Channel Mechanism' name='pas'>
          <bio:parameter name='gmax' value='0.01'>
            <bio:group>all</bio:group>
          </bio:parameter>
          <bio:parameter name='gmax' value='0.259041'>
            <bio:group>all</bio:group>
          </bio:parameter>
          <bio:parameter name='e' value='-65'>
            <bio:group>all</bio:group>
          </bio:parameter>
        </bio:mechanism>
        <bio:spec_capacitance xmlns:bio='http://morphml.org/biophysics/schema'>
          <bio:parameter value='1'>
            <bio:group>all</bio:group>
          </bio:parameter>
        </bio:spec_capacitance>
        <bio:spec_axial_resistance xmlns:bio='http://morphml.org/biophysics/schema'>
          <bio:parameter value='0.2'>
            <bio:group>all</bio:group>
          </bio:parameter>
        </bio:spec_axial_resistance>
      </biophysics>
  </cell>
</cells>
</neuroml>

Loading data, please wait...