L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)

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Accession:155057
Using a heavily constrained biophysical model of a L5 PFC microcircuit we investigate the mechanisms that underlie persistent activity emergence (ON) and termination (OFF) and search for the minimum network size required for expressing these states within physiological regimes.
References:
1 . Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P (2013) Induction and modulation of persistent activity in a layer V PFC microcircuit model. Front Neural Circuits 7:161 [PubMed]
2 . Papoutsi A, Sidiropoulou K, Poirazi P (2014) Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model. PLoS Comput Biol 10:e1003764 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Connectionist Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I CAN; I Potassium; I R; I_AHP;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Working memory;
Implementer(s): Papoutsi, Athanasia [athpapoutsi at gmail.com];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I CAN; I Potassium; I R; I_AHP;
 
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L5microcircuit
mechanism
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