L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)

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Accession:155057
Using a heavily constrained biophysical model of a L5 PFC microcircuit we investigate the mechanisms that underlie persistent activity emergence (ON) and termination (OFF) and search for the minimum network size required for expressing these states within physiological regimes.
References:
1 . Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P (2013) Induction and modulation of persistent activity in a layer V PFC microcircuit model. Front Neural Circuits 7:161 [PubMed]
2 . Papoutsi A, Sidiropoulou K, Poirazi P (2014) Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model. PLoS Comput Biol 10:e1003764 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite; Connectionist Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I CAN; I Potassium; I R; I_AHP;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Working memory;
Implementer(s): Papoutsi, Athanasia [athpapoutsi at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I A; I CAN; I Potassium; I R; I_AHP;
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L5microcircuit
mechanism
ampa.mod
ampain.mod
cadyn.mod
cal.mod
can.mod
car.mod
cat.mod
gabaa.mod *
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kdr.mod *
naf.mod
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netstim.mod *
NMDA.mod
NMDA_syn.mod
sinclamp.mod *
vecstim.mod *
                            
TITLE  H-current 
: Updated to use Cvode by Yiota Poirazi 12/1/2005

NEURON {
	SUFFIX h
        RANGE  gbar,vhalf, K, taun, ninf, g, ihi
	USEION hi READ ehi WRITE ihi VALENCE 1      
}

UNITS {
	(um) = (micrometer)
	(mA) = (milliamp)
	(uA) = (microamp)
	(mV) = (millivolt)
	(pmho) = (picomho)
	(mmho) = (millimho)
}

:INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}

PARAMETER {              : parameters that can be entered when function is called in cell-setup
        ena    = 55    (mV)
        ehi     = -10   (mV)
	K      = 10.0   (mV)	
	gbar   = 0     (mho/cm2)  : initialize conductance to zero
	vhalf  = -90   (mV)       : half potential
}	


STATE {                : the unknown parameters to be solved in the DEs
	n
}

ASSIGNED {             : parameters needed to solve DE
        v 
	ihi (mA/cm2)
	ninf
	taun (ms)
	g
}

        


INITIAL {               : initialize the following parameter using states()
	rates()	
	n = ninf
	g = gbar*n
	ihi = g*(v-ehi)
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	g = gbar*n
	ihi = g*(v-ehi)  
}

DERIVATIVE states {
	rates()
        n' = (ninf - n)/taun
}

PROCEDURE rates() {  
 
 	if (v > -10) {
	   taun = 1
	} else {
           taun = 2*(1/(exp((v+145)/-17.5)+exp((v+16.8)/16.5)) + 10) 

	}  
         ninf = 1 - (1 / (1 + exp((vhalf - v)/K)))                  :steady state value
}




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