Learning intrinsic excitability in Medium Spiny Neurons (Scheler 2014)

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Accession:155131
"We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way. We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parameterization of individual ion channels on the neuronal membrane potential-curent relationship (activation function). We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions. ... "
Reference:
1 . Scheler G (2014) Learning intrinsic excitability in medium spiny neurons F1000Research 2:88
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell;
Channel(s): I A; I K; I h; I K,Ca; I Calcium; I A, slow; I Cl, leak; I Ca,p;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): Kv4.2 KCND2; Kv1.1 KCNA1; Kv1.2 KCNA2; Kv4.3 KCND3; Kv1.4 KCNA4; Kv1.3 KCNA3; Kv1.5 KCNA5; Kv3.3 KCNC3; Cav3.2 CACNA1H; Cav3.1 CACNA1G; Cav3.3 CACNA1I; Cav1.3 CACNA1D; Cav1.1 CACNA1S; Cav1.2 CACNA1C; KCa2.1 KCNN1; Kv2.1 KCNB1; Kv3.1 KCNC1; HCN Cnga1; Cav2.1 CACNA1A; Cav2.2 CACNA1B; KCa2.2 KCNN2; Kv1.9 Kv7.1 KCNQ1; IRK; NR2A GRIN2A; NR2B GRIN2B; Kv3.4 KCNC4; Kv4.1 KCND1;
Transmitter(s): Gaba; Glutamate; Ions;
Simulation Environment: MATLAB;
Model Concept(s): Intrinsic plasticity;
Implementer(s): Schumann, Johann [johann.schumann at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; GabaA; AMPA; NMDA; I A; I K; I h; I K,Ca; I Calcium; I A, slow; I Cl, leak; I Ca,p; Gaba; Glutamate; Ions;
% ical.m
% Calcium channel
% from: model6/ical_tsubo.m
%
% modeled after Tsubo and Gruber (g_CaL and offset -20mV)
% with offset 7mV to match Mahonetal2000
% using m,h and alpha, beta formulation
% returns also steady-state values
%
%	$Revision:$
%
function [I_CaL, dm, dh, m_inf, h_inf] = ical_tsubo(V_m, m, h)

shift=0;
%shift=20;

E_CaL = 140;	% mV
%g_CaL = 0.01;	% mS/cm^2
g_CaL = 0.1;	% mS/cm^2 [Gruber]

al_m = mylinexp(V_m, 0.055, -27+7-shift, -3.8);	% type 3 [Tsubo]
be_m = myexp(V_m, 0.94, -75+7-shift, -17);		% type 1

m_inf = al_m/(al_m + be_m);

al_h = myexp(V_m, 0.000457, -13+7-shift, -50);	% type 1
be_h = mylog(V_m, 0.0065, -15+7-shift, -28);		% type 2
h_inf = al_h/(al_h + be_h);

I_CaL = g_CaL*(m^2)*h*(V_m - E_CaL);

dm = al_m*(1-m) - be_m*m;
dh = al_h*(1-h) - be_h*h;

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