Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
ModelDB is moving. Check out our new site at
The corresponding page is
Dentate gyrus network model (Tejada et al 2014)
Download zip file
Help downloading and running models
Versions on GitHub
" ... Here we adapted an existing computational model of the dentate gyrus (J Neurophysiol 93: 437-453, 2005) by replacing the reduced granule cell models with morphologically detailed models coming from (3D) reconstructions of mature cells. ... Different fractions of the mature granule cell models were replaced by morphologically reconstructed models of newborn dentate granule cells from animals with PILO-induced Status Epilepticus, which have apical dendritic alterations and spine loss, and control animals, which do not have these alterations. This complex arrangement of cells and processes allowed us to study the combined effect of mossy fiber sprouting, altered apical dendritic tree and dendritic spine loss in newborn granule cells on the excitability of the dentate gyrus model. Our simulations suggest that alterations in the apical dendritic tree and dendritic spine loss in newborn granule cells have opposing effects on the excitability of the dentate gyrus after Status Epilepticus. Apical dendritic alterations potentiate the increase of excitability provoked by mossy fiber sprouting while spine loss curtails this increase. "
Tejada J, Garcia-Cairasco N, Roque AC (2014) Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus.
PLoS Comput Biol
Tejada J, Arisi GM, García-Cairasco N, Roque AC (2012) Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable.
(Click on a link to find other models with that property)
Dentate gyrus granule GLU cell;
Dentate gyrus mossy cell;
Dentate gyrus basket cell;
Dentate gyrus hilar cell;
I L high threshold;
I T low threshold;
Spatio-temporal Activity Patterns;
Tejada, Julian [julian.tejada at gmail.com];
for information about:
Dentate gyrus granule GLU cell
I L high threshold
I T low threshold
File not selected
<- Select file from this column.
Loading data, please wait...