Intrinsic sensory neurons of the gut (Chambers et al. 2014)

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Accession:155796
A conductance base model of intrinsic neurons neurons in the gastrointestinal tract. The model contains all the major voltage-gated and calcium-gated currents observed in these neurons. This model can reproduce physiological observations such as the response to multiple brief depolarizing currents, prolonged depolarizing currents and hyperpolarizing currents. This model can be used to predict how different currents influence the excitability of intrinsic sensory neurons in the gut.
Reference:
1 . Chambers JD, Bornstein JC, Gwynne RM, Koussoulas K, Thomas EA (2014) A detailed, conductance-based computer model of intrinsic sensory neurons of the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 307:G517-32 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Gastrointestinal tract intrinsic sensory neuron;
Channel(s): I Na,p; I Na,t; I K,leak; I K,Ca; I CAN; I Mixed; I Na, leak; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.3 SCN3A; Nav1.7 SCN9A; Nav1.9 SCN11A SCN12A;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Chambers, Jordan [jordandchambers at gmail.com];
Search NeuronDB for information about:  I Na,p; I Na,t; I K,leak; I K,Ca; I CAN; I Mixed; I Na, leak; Ca pump;
create soma
soma {
    diam = 25.0
    L = 49.0
    Ra = 30
    cm = 1
}
soma {
    //nseg = int((2*L/(0.1*lambda_f(100))+.9)/2)*2 + 1
    nseg = 10
}

soma {
    insert pas
    e_pas = -55.0
    g_pas = 4e-5
    
    insert nav13
    gbar_nav13 = 3e-1
    sh_nav13 = 8
    tha_nav13 = -30.5
    qa_nav13 = 4.5
    Ra_nav13 = 0.4
    Rb_nav13 = 0.135
    thi1_nav13 = -30
    thi2_nav13 = -30
    qd_nav13 = 1.5
    qg_nav13 = 1.5
    mmin_nav13 = 0.02	
    hmin_nav13 = 0.5			
    q10_nav13 = 2
    Rg_nav13 = 0.01
    Rd_nav13 = 0.03
    qq_nav13 = 10
    tq_nav13 = -50
    thinf_nav13 = -55
    qinf_nav13 = 4
    vhalfs_nav13 = -60
    a0s_nav13 = 0.0003
    zetas_nav13 = 12
    gms_nav13 = 0.2
    smax_nav13 = 10
    vvh_nav13 = -58
    vvs_nav13 = 2
    ar2_nav13 = 1
    
    insert nav17
    gnabar_nav17 = 1e-1
    mam_nav17 = 5
    sam_nav17 = -12.08
    mbm_nav17 = 72.7
    sbm_nav17 = 16.7
    mah_nav17 = 122.35
    sah_nav17 = 15.29
    mas_nav17 = 93.9
    sas_nav17 = 16.6
    alphaD_nav17 = 0.05
    betaD_nav17 = 0.02
    
    insert nap
    gbar_nap = 1e-5
    
    insert jcal
    TotalBuffer_jcal = 5e-3
    k1buf_jcal = 3
    k2buf_jcal = 0.005
    depth_jcal = 1
    taur_jcal = 1e1
    cainf_jcal = 5e-5
    cain_jcal = 0.5e0
    gcaca_jcal = 0.2e-4
    cacamid_jcal = 1e-4
    cacas_jcal = 2e-5
    
    insert can
    gbar_can = 4e-2
    mafac_can = 0.1
    mamid_can = -15
    maslope_can = 5
    mbfac_can = 0.5
    mbmid_can = -5
    mbslope_can = 10
    hafac_can = 0.01
    hamid_can = 50
    haslope_can = 15
    hbfac_can = 0.2
    hbmid_can = 40
    hbslope_can = 17
    
    insert kdr
    gbar_kdr = 1e-2
    nimid_kdr = 0
    nislope_kdr = 25
    ntmid_kdr = 27
    ntslope_kdr = 15
    
    insert ka
    gbar_ka = 1e-2
    amid_ka = 30
    aslope_ka = 20
    bmid_ka = 80
    bslope_ka = 6
    btau_ka = 15
    atau_ka = 0.5
    
    insert kca_fast
    gbar_kca_fast = 3e-2
    cac_kca_fast = 7e-4
    cas_kca_fast = 7.5e-5
    v1_kca_fast = 50
    v2_kca_fast = 53.5
    s1_kca_fast = 11
    s2_kca_fast = 27
    aspeed_kca_fast = 1
    bspeed_kca_fast = 1

    insert kca_slow
    gbar_kca_slow = 5e0
    Ra_kca_slow = 0.3e-3
    Rb_kca_slow = 6e-5
    cac_kca_slow = 2.5e-4
    cas_kca_slow = 2.5e-5
    
    insert cansc
    gbar_cansc = 1e-4
    beta_cansc = 1e-4
    cac_cansc = 6e-4
    cas_cansc = 2e-5
    ratc_cansc = 1e-1
    x_cansc = 1
    erev_cansc = -38
    taumin_cansc = -0.1e0
    
    insert ih
    gbar_ih = 1e-4
    vhalf_ih = -72
    vslope1_ih = 8.2
    vslope2_ih = 11.9
    tmc1_ih = 537
    tmc2_ih = 56
    
}

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