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Information transmission in cerebellar granule cell models (Rossert et al. 2014)
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" ... In this modeling study we analyse how electrophysiological granule cell properties and spike sampling influence information coded by firing rate modulation, assuming no signal-related, i.e., uncorrelated inhibitory feedback (open-loop mode). A detailed one-compartment granule cell model was excited in simulation by either direct current or mossy-fiber synaptic inputs. Vestibular signals were represented as tonic inputs to the flocculus modulated at frequencies up to 20 Hz (approximate upper frequency limit of vestibular-ocular reflex, VOR). Model outputs were assessed using estimates of both the transfer function, and the fidelity of input-signal reconstruction measured as variance-accounted-for. The detailed granule cell model with realistic mossy-fiber synaptic inputs could transmit infoarmation faithfully and linearly in the frequency range of the vestibular-ocular reflex. ... "
Rössert C, Solinas S, D'Angelo E, Dean P, Porrill J (2014) Model cerebellar granule cells can faithfully transmit modulated firing rate signals.
Front Cell Neurosci
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Neuron or other electrically excitable cell;
Cerebellum interneuron granule GLU cell;
Solinas, Sergio [solinas at unipv.it];
Roessert, Christian [christian.a at roessert.de];
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Cerebellum interneuron granule GLU cell
Other models using units.py:
Basis for temporal filters in the cerebellar granular layer (Roessert et al. 2015)
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