Effects of spinal cord stimulation on WDR dorsal horn network (Zhang et al 2014)

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Accession:168414
" ... To study the mechanisms underlying SCS (Spinal cord stimulation), we constructed a biophysically-based network model of the dorsal horn circuit consisting of interconnected dorsal horn interneurons and a wide dynamic range (WDR) projection neuron and representations of both local and surround receptive field inhibition. We validated the network model by reproducing cellular and network responses relevant to pain processing including wind-up, A-fiber mediated inhibition, and surround receptive field inhibition. ..." See paper for more.
Reference:
1 . Zhang TC, Janik JJ, Grill WM (2014) Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. J Neurophysiol 112:552-67 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Wide dynamic range neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Glutamate; Glycine;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Zhang, Tianhe [tz5@duke.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate; Glycine;
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ZhangEtAl2014
Critical Mod Files
AMPA_DynSyn.mod
B_A.mod
B_DR.mod
B_NA.mod
CaIntraCellDyn.mod *
GABAa_DynSyn.mod *
GABAb_DynSyn.mod *
Glycine_DynSyn.mod
HH2.mod *
HH2new.mod *
iCaAN.mod *
iCaL.mod
iKCa.mod *
iNaP.mod *
KDR.mod
KDRI.mod
NK1_DynSyn.mod *
NMDA_DynSyn.mod *
SS.mod
vsource.mod *
                            
TITLE vsource.mod
COMMENT
Patterned after svclmp.mod, a single electrode Voltage clamp mechanism.
Unlike svclmp.mod, this has one level--amp--and it delivers current i 
for t<=toff (even t<0).

Clamp is on at time 0, and off after time toff.
When clamp is off the injected current is 0.
i is the injected current, vc measures the control voltage.

For other comments and important implementational details, 
especially "why SOLVE icur METHOD after_cvode ???", 
see the comments in svclmp.mod
ENDCOMMENT

NEURON {
	POINT_PROCESS Vsource
	ELECTRODE_CURRENT i
	RANGE toff, amp, rs, vc, i
}

UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(uS) = (microsiemens)
}


PARAMETER {
	rs = 1 (megohm) <1e-9, 1e9>
	toff (ms) 	  amp (mV)
}

ASSIGNED {
	v (mV)	: automatically v + vext when extracellular is present
	i (nA)
	vc (mV)
	on
}

INITIAL {
	on = 1
}

BREAKPOINT {
	SOLVE icur METHOD after_cvode
	vstim()
}

PROCEDURE icur() {
	if (on) {
		i = (vc - v)/rs
	}else{
		i = 0
	}
}

PROCEDURE vstim() {
	on = 1
	if (toff) {at_time(toff)}
	if (t < toff) {
		vc = amp
	}else {
		vc = 0
		on = 0
	}
	icur()
}

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