Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

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Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
/
SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
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 */
 * is calculated using these two parameters in each section.
 * which affects the number of compartments since lambda_f
 * Need to call this again, because we have changed Ra and cm,
/* 

} 
	ena=90
	gna_Naaxon = 0.0117
	insert Naaxon
	ek=-95
	cm=0.9
	Ra=300
	gbar_Ikdrsaxon = 0.00023
	insert Ikdrsaxon
	gbar_Ikdrfaxon = 0.0006
	insert Ikdrfaxon
	gkl_Kleakaxon=1.7742e-05
	insert Kleakaxon
	erev_passaxon=-66.164
	g_passaxon=6.1771e-05
for i=0,4 axon[i] {insert passaxon

}
        }
          insert Ih        if (hD == 1) {	ena=90	gna_Nadend = 0.0117
	insert Nadend
	gkbar_kca = 0.00055
	insert kca
	gbar_cat = 0.00025
	insert cat
	insert cad
	gcalbar_cal = 0.0025
	insert cal
	ek=-95
	cm=0.9
	Ra=300
	gbar_Ika = 0.00025
	insert Ika
	gbar_Ikdrs = 0.00023
	insert Ikdrs
	gbar_Ikdrf = 0.0006
	insert Ikdrf
	gbar_IMminret=0 // 0.000075
	insert IMminret
	gbar_IM = 0.000075
	insert IM
	gkl_Kleaksd=3.2258e-06
	insert Kleaksd
	erev_passsd=-66.164
	g_passsd=1.1231e-05
	insert passsd
for i=0,51 dendrite[i] {

}
	eh=-32
	gkhbar_Ih = 0.00005
	insert Ih
	ena=90
	gna_Nasoma = 0.0107
	insert Nasoma
	gbar_Ika = 0.00025
	insert Ika
	gbar_Ikdrs = 0.00023
	insert Ikdrs
	gbar_Ikdrf = 0.0006
	insert Ikdrf
	gbar_IMminret=0 // 0.000075
	insert IMminret
	gbar_IM=0.000075
	insert IM
	ek=-95
	cm=0.9
	Ra=300
	gkl_Kleaksd=3.2258e-06
	insert Kleaksd
	erev_passsd=-66.164
	g_passsd=1.1231e-05
	insert passsd
for i=0,7 soma[i] {

celsius=24
load_file("Richytrunctest2.hoc")

load_file("nrngui.hoc")

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