Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
/
SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
b0VIM 7.3y��T�c�
vsekulicosgiliath.local~vsekulic/Dropbox/research/project/2006-RichyandStarfish-dendIh/ipsc-cihr.hocutf-8
U3210#"! Utp�adi����������jibH32+���������e1�
�
�
�
�
~
n
`
Q
P
&


�������tdVGF
��������k[M>=�
�
�
�
�
�
�
�
_
N
?
/
.

�	�	�	�	�	�	�	x	w	L	;	,			�������scb7&�����l)������kY4"�����}XF!����ta:'����yR?IcIcIconn18.weight = 1Iconn18 = new NetCon(IMSspike, Isyn18)Iconn17.weight = 1Iconn17 = new NetCon(IMSspike, Isyn17)Iconn16.weight = 1Iconn16 = new NetCon(IMSspike, Isyn16)Iconn15.weight = 1Iconn15 = new NetCon(IMSspike, Isyn15)Iconn14.weight = 1Iconn14 = new NetCon(IMSspike, Isyn14)Iconn13.weight = 1Iconn13 = new NetCon(IMSspike, Isyn13)Iconn12.weight = 1Iconn12 = new NetCon(IMSspike, Isyn12)Iconn11.weight = 1Iconn11 = new NetCon(IMSspike, Isyn11)Iconn10.weight = 1Iconn10 = new NetCon(IMSspike, Isyn10)Iconn9.weight = 1Iconn9 = new NetCon(IMSspike, Isyn9)Iconn8.weight = 1Iconn8 = new NetCon(IMSspike, Isyn8)Iconn7.weight = 1Iconn7 = new NetCon(IMSspike, Isyn7)Iconn6.weight = 1Iconn6 = new NetCon(IMSspike, Isyn6)Iconn5.weight = 1Iconn5 = new NetCon(IMSspike, Isyn5)Iconn4.weight = 1Iconn4 = new NetCon(IMSspike, Isyn4)Iconn3.weight = 1Iconn3 = new NetCon(IMSspike, Isyn3)Iconn2.weight = 1Iconn2 = new NetCon(IMSspike, Isyn2)Iconn1.weight = 1Iconn1 = new NetCon(IMSspike, Isyn1)objref Iconn15, Iconn16, Iconn17, Iconn18objref Iconn8, Iconn9, Iconn10, Iconn11, Iconn12, Iconn13, Iconn14objref Iconn1, Iconn2, Iconn3, Iconn4, Iconn5, Iconn6, Iconn7Isyn18.i = -0.6Isyn18.e = -85Isyn18.tau = 8.5dendrite[19] Isyn18 = new ExpSyn(0.590909)Isyn17.i = -0.6Isyn17.e = -85Isyn17.tau = 8.5dendrite[21] Isyn17 = new ExpSyn(0.327586)Isyn16.i = -0.6Isyn16.e = -85Isyn16.tau = 8.5dendrite[35] Isyn16 = new ExpSyn(0.0853658)Isyn15.i = -0.6Isyn15.e = -85Isyn15.tau = 8.5dendrite[29] Isyn15 = new ExpSyn(0.318182)Isyn14.i = -0.6Isyn14.e = -85Isyn14.tau = 8.5dendrite[21] Isyn14 = new ExpSyn(0.189655)Isyn13.i = -0.6Isyn13.e = -85Isyn13.tau = 8.5dendrite[45] Isyn13 = new ExpSyn(0.364865)Isyn12.i = -0.6Isyn12.e = -85Isyn12.tau = 8.5dendrite[1] Isyn12 = new ExpSyn(0.685185)Isyn11.i = -0.6Isyn11.e = -85Isyn11.tau = 8.5dendrite[25] Isyn11 = new ExpSyn(0.166667)Isyn10.i = -0.6Isyn10.e = -85Isyn10.tau = 8.5dendrite[3] Isyn10 = new ExpSyn(0.94898) Isyn9.i = -0.6Isyn9.e = -85Isyn9.tau = 8.5dendrite[1] Isyn9 = new ExpSyn(0.759259) Isyn8.i = -0.6Isyn8.e = -85Isyn8.tau = 8.5dendrite[29] Isyn8 = new ExpSyn(0.572727) Isyn7.i = -0.6Isyn7.e = -85Isyn7.tau = 8.5dendrite[25] Isyn7 = new ExpSyn(0.351852) Isyn6.i = -0.6Isyn6.e = -85Isyn6.tau = 8.5dendrite[3] Isyn6 = new ExpSyn(0.72449) Isyn5.i = -0.6Isyn5.e = -85Isyn5.tau = 8.5dendrite[19] Isyn5 = new ExpSyn(0.863636) Isyn4.i = -0.6Isyn4.e = -85Isyn4.tau = 8.5dendrite[33] Isyn4 = new ExpSyn(0.282609) Isyn3.i = -0.6Isyn3.e = -85Isyn3.tau = 8.5dendrite[1] Isyn3 = new ExpSyn(0.944444) Isyn2.i = -0.6Isyn2.e = -85Isyn2.tau = 8.5dendrite[38] Isyn2 = new ExpSyn(0.754902) Isyn1.i = -0.6Isyn1.e = -85Isyn1.tau = 8.5dendrite[33] Isyn1 = new ExpSyn(0.282609) objref Isyn14, Isyn15, Isyn16, Isyn17, Isyn18objref Isyn8, Isyn9, Isyn10, Isyn11, Isyn12, Isyn13objref Isyn1, Isyn2, Isyn3, Isyn4, Isyn5, Isyn6, Isyn7IMSspike.noise = 0IMSspike.start = 500//IMSspike.number 50//IMSspike.interval = 100// 10HzIMSspike.number = 40IMSspike.interval = 125// 8Hz//IMSspike.number 25//IMSspike.interval = 200// 5Hzsoma[0] IMSspike = new NetStim(0.5)objref IMSspikeholdclamp.amp=0h=3e-05injclamp.amp = 0tstop = 3500// Load R4 straight from DB. That's all.

Loading data, please wait...