Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

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Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
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SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
COMMENT

Ih current	 - hyperpolarization-activated nonspecific Na and K channel
		 - contributes to the resting membrane potential
		 - controls the afterhyperpolarization

Conductance density is modified by Vlad as through database

Reference:
Saraga, F. (2003). Active dendrites and spike propagation in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons. The Journal of physiology, 552(3), 673-689.

ENDCOMMENT

UNITS {
        (mA) = (milliamp)
        (mV) = (millivolt)
}
 
NEURON {
        SUFFIX Ih
        USEION h READ eh WRITE ih VALENCE 1
        RANGE gkhbar,ih,g
        GLOBAL rinf
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
 
PARAMETER {
        v (mV)
        p = 5 (degC)
        dt (ms)
	gkhbar = 0.000005 (mho/cm2)
        eh = -32.9 (mV)

	t1 = 1 (ms)
	t2 = 1
	t3 = -0.116 (1/mV)
	t4 = -17.9
	t5 = 1
	t6 = 0.09 (1/mV)
	t7 = -1.84
	t8 = 100 (ms)
}
 
STATE {
        r
}
 
ASSIGNED {
        ih (mA/cm2)
	rinf 
	tau_r	(ms)
	g (S/cm2)
}
 
BREAKPOINT {
        SOLVE state METHOD cnexp
        ih = gkhbar*r*(v - eh)
	g = gkhbar*r
}
 
INITIAL {
	rates(v, t1, t2, t3, t4, t5, t6, t7, t8)
	r = rinf
}

DERIVATIVE state { :Computes state variable h at current v and dt.
	rates(v, t1, t2, t3, t4, t5, t6, t7, t8)
	r' = (rinf - r)/tau_r
}
UNITSOFF

PROCEDURE rates(v(mV), t1 (ms), t2, t3(1/mV), t4, t5, t6(1/mV), t7, t8(ms)) {
	rinf = 1/(1 + exp((v+84)/10.2))
	tau_r = t1/(t2*exp(t3*v+t4)+t5*exp(t6*v+t7)) + t8 + 1e-8
}
 
UNITSON

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