Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

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Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
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SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
TITLE KDRS
: Slow K-DR current for hippocampal interneurons from Lien et al (2002)
: M.Migliore Jan. 2003

NEURON {
	SUFFIX Ikdrsaxon
	USEION k READ ek WRITE ik
	RANGE  gbar, ik
	GLOBAL minf, mtau, hinf
}

PARAMETER {
	gbar = 0.0002   	(mho/cm2)	
								
	celsius		(degC)
	ek		(mV)            : must be explicitly def. in hoc
	v 		(mV)
	a0m=0.015
	vhalfm=-25	(mV)
	zetam=0.15
	gmm=0.5
	htau=1000	(ms)
	mmin=7		(ms)
	q10=3
	f=0.93
}


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

ASSIGNED {
	ik 		(mA/cm2)
	minf 		mtau (ms)	 	
	hinf	 	
}
 

STATE { m h}

BREAKPOINT {
        SOLVE states METHOD cnexp
	ik = gbar*m*h*(v - ek)
} 

INITIAL {
	trates(v)
	m=minf  
	h=hinf  
}

DERIVATIVE states {   
        trates(v)      
        m' = (minf-m)/mtau
        h' = (hinf-h)/htau
}

PROCEDURE trates(v(mV)) {  
	LOCAL qt
        qt=q10^((celsius-23(degC))/10(degC))
        minf = (1/(1 + exp(-(v+41.9(mV))/23.1(mV))))^4
	mtau = betm(v)/(qt*a0m*1(/ms)*(1+alpm(v)))
	if (mtau<mmin) {mtau=mmin}
        hinf = f*(1/(1 + exp((v+52.2(mV))/15.2(mV))))+(1-f)
}

FUNCTION alpm(v(mV)) {
  alpm = exp(zetam*(v-vhalfm)*1(/mV)) 
}

FUNCTION betm(v(mV)) {
  betm = exp(zetam*gmm*(v-vhalfm)*1(/mV)) 
}

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