Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

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Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
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SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
proc print_tau() {
    printf("%g %g %g %g %g %g %g %g | %g %g %g %g %g %g\n", t1, t2, t3, t4, t5, t6, t7, t8, dendIh_growth, holdclamp.amp, Rm, Cm, gkhbar_tot(), gkhbar_scale)
}

func gkhbar_tot() {
    gkhbar_t = 0
    forall for(x) {
        if (!issection("axon.*") && (issection("soma.*") || (issection("dendrite.*") && hD == 1))) {

            // Calculates total conductance, in pS
            // 10^4 factor required to convert from S/cm^2 to pS/um^2.
            // gkhbar_t then has units of pS.
            gkhbar_t = gkhbar_t + (gkhbar_Ih(x) * 10^4 * area(x))
        }
    }

    // Return in nS so we get, e.g., 1.443 instead of 1443 for Richy (uniform dendritic Ih with gkhbar=0.1pS/um^2).
    return gkhbar_t * 10^-3
}

/*
 * Completely unnecessary! Just set h = 0 and init() in params.hoc will take care of the rest!
 */
proc gkhbar_Ih_off() {
    forall {
        if (issection("soma.*")) {
            gkhbar_Ih = 0
        } else if (issection("dend.*") && hD == 1) {
            for (x) {
                gkhbar_Ih(x) = 0
            }
        }
    }
}

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