Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:182797
The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.
Reference:
1 . Sekulic V, Chen TC, Lawrence JJ, Skinner FK (2015) Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Front Synaptic Neurosci 7:2 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ;
Channel(s): I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP;
/
SekulicEtAl2015
04525047--90nA
04610022--90nA
README.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
.initactivesdRichy.hoc.swp
.ipsc-cihr.hoc.swp
active_mods.hoc
celltestt.dat
dendIh_funcs.hoc
frontiers_Fig10.hoc
ihold_funcs.hoc
init_d_lambda_Richy_trunc.hoc
init_d_lambda_Starfish_full.hoc
init_exp.hoc
init_Richy_RN.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initactivesdStarfishfull.hoc
iprotocol.hoc
ipsc.hoc
ipsc-cihr.hoc
mosinit.hoc
nsegfuncs.hoc
param_active_cond.hoc
params.hoc
Richytrunctest2.hoc
rn.hoc
screen.png
screen1.png
Starfishfull.hoc
Starfishtrunc.hoc
startup_R3.sh
startup_R4.sh
startup_S3.sh
startup_S4.sh
                            
load_file("nrngui.hoc")

load_file("Starfishfull.hoc")
celsius=24

for i=0,8 soma[i] {
	insert passsd
	g_passsd=1.273e-05
	erev_passsd=-59.419
	insert Kleaksd
	gkl_Kleaksd=3.1262e-06
	Ra=300
	cm=0.9
	ek=-95
	insert IM
	gbar_IM=0.000012
        insert Ikdrf
        gbar_Ikdrf = 0.0006
        insert Ikdrs
        gbar_Ikdrs = 0.00023
        insert Ika
        gbar_Ika = 0.00025
	insert Nasoma
	gna_Nasoma = 0.0107
	ena=90
	insert Ih
	gkhbar_Ih=0.00005
	eh=-32
}

for i=0,43 dendrite[i] {
	insert passsd
	g_passsd=1.273e-05
	erev_passsd=-59.419
	insert Kleaksd
	gkl_Kleaksd=3.1262e-06
	insert IM
        gbar_IM = 0.000012
        insert Ikdrf
        gbar_Ikdrf = 0.0006
        insert Ikdrs
        gbar_Ikdrs = 0.00023
        insert Ika
        gbar_Ika = 0.00025
	Ra=300
	cm=0.9
	ek=-95
        insert cal
        gcalbar_cal = 0.0025
        insert cad
        insert cat
        gbar_cat = 0.00025
        insert kca
        gkbar_kca = 0.00055
        insert Nadend
        gna_Nadend = 0.0117
        ena=90
}

for i=0,196 axon[i] {insert passaxon
	g_passaxon=4.3282e-05
	erev_passaxon=-59.419
	insert Kleakaxon
	gkl_Kleakaxon=1.0629e-05
	insert Ikdrf
        gbar_Ikdrf = 0.0006
        insert Ikdrs
        gbar_Ikdrs = 0.00023
	Ra=300
	cm=0.9
	ek=-95
	insert Nadend
	gna_Nadend = 0.0117
	ena=90
} 

/*
 * Need to call this again, because we have changed Ra and cm,
 * which affects the number of compartments since lambda_f
 * is calculated using these two parameters in each section.
 */
geom_nseg()

Loading data, please wait...