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NMDA spikes in basal dendrites of L5 pyramidal neurons (Polsky et al. 2009)
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"... In apical dendrites of neocortical pyramidal neurons, calcium spikes are known to contribute to burst generation, but a comparable understanding of basal dendritic mechanisms is lacking. Here we show that NMDA spikes in basal dendrites mediate both detection and generation of bursts through a postsynaptic mechanism. High-frequency inputs to basal dendrites markedly facilitated NMDA spike initiation compared with low-frequency activation or single inputs. ..."
Polsky A, Mel B, Schiller J (2009) Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons.
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Action Potential Initiation;
Polsky, Alon [alonpol at tx.technion.ac.il];
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Neocortex L5/6 pyramidal GLU cell
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