ModelDB: Kinetic synaptic models applicable to building networks (Destexhe et al 1998)

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Kinetic synaptic models applicable to building networks (Destexhe et al 1998)

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Accession:18500

Simplified AMPA, NMDA, GABAA, and GABAB receptor models useful for building networks are described in a book chapter. One reference paper synthesizes a comprehensive general description of synaptic transmission with Markov kinetic models which is applicable to modeling ion channels, synaptic release, and all receptors. Also a simple introduction to this method is given in a seperate paper Destexhe et al Neural Comput 6:14-18 , 1994). More information and papers at http://cns.iaf.cnrs-gif.fr/Main.html and through email: Destexhe@iaf.cnrs-gif.fr
References:
1 . Destexhe A, Mainen ZF, Sejnowski TJ (1994) Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. J Comput Neurosci 1:195-230 [PubMed]
2 . Destexhe A, Mainen ZF, Sejnowski TJ (1998) Kinetic models of synaptic transmission Methods In Neuronal Modeling, Koch C:Segev I, ed. pp.1
3 . Destexhe A, Mainen Z, Sejnowski TJ (1994) An efficient method for computing synaptic conductances based on a kinetic model of receptor binding Neural Comput 6:14-18

Model Information (Click on a link to find other models with that property)

Model Type:	Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):	GabaA; GabaB; AMPA; NMDA; Glutamate; Gaba;
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	NEURON;
Model Concept(s):	Ion Channel Kinetics; Simplified Models; Markov-type model;
Implementer(s):	Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]; Mainen, Zach [Mainen at cshl.edu];