VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)

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Accession:185330
" ... Here we present a biophysical model of a DA VTA neuron based on 3D morphological reconstruction and electrophysiological data, showing how opiates withdrawal-driven morphological and electrophysiological changes could affect the firing rate and discharge pattern...."
Reference:
1 . Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. Neuroscience 322:195-207 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Addiction;
Implementer(s): Enrico, Paolo [enrico at uniss.it];
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EnricoEtAl2016
README.html
cabal.mod *
cachan.mod
capump.mod *
dop.mod *
hh3.mod
IhDA.mod
kca.mod
nabalan.mod
netstimd.mod
newleak.mod
nmdanet.mod *
pump.mod *
CellDef.hoc
ctrlfiring_cnt.txt
DA_release.ses
DA_release_final.hoc
DA_release_withdrawal_final.hoc
DA_release_withdrawal_final_noGLU.hoc
firing_cnt.txt
fixnseg.hoc *
mosinit.hoc
screenshot.png
screenshot2.png
                            
TITLE I-h channel from Magee 1998 for distal dendrites

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	
}

PARAMETER {
	v 		(mV)
      ehd=-30  		(mV)        
	ghdbar=0.001	(mho/cm2) :  must be explicitly def. in hoc
	vh=-95 (mV) : must be explicitly def. in hoc
	tc : must be explicitly def. in hoc
        vhalft=-112   	(mV)
        a0t=0.0016      	(/ms)
        zetat=2.2    	(1)
        gmt=.9   	(1)
	k=8
}

NEURON {
	SUFFIX hd
	NONSPECIFIC_CURRENT i
        RANGE ghdbar
        GLOBAL linf,taul, vh, tc
}

STATE {
        l
}

ASSIGNED {
	  i (mA/cm2)
        linf      
        taul
        ghd
}

INITIAL {
	rate(v)
	l=linf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	ghd = ghdbar*l
	i = ghd*(v-ehd)

}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rate(v)
        l' =  (linf - l)/taul
}

FUNCTION alpt(v(mV)) {
  alpt = exp(0.0378*zetat*(v-vhalft)) 
}

FUNCTION bett(v(mV)) {
  bett = exp(0.0378*zetat*gmt*(v-vhalft)) 
}


PROCEDURE rate(v) { :callable from hoc
	LOCAL a
        linf = 1/(1 + exp((v-vh)/k))
:        taul = tc
        a = alpt(v)
        taul = bett(v)/(a0t*(1+a))
}

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