VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:185330
" ... Here we present a biophysical model of a DA VTA neuron based on 3D morphological reconstruction and electrophysiological data, showing how opiates withdrawal-driven morphological and electrophysiological changes could affect the firing rate and discharge pattern...."
Reference:
1 . Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. Neuroscience 322:195-207 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Addiction;
Implementer(s): Enrico, Paolo [enrico at uniss.it];
/
EnricoEtAl2016
README.html
cabal.mod *
cachan.mod
capump.mod *
dop.mod *
hh3.mod
IhDA.mod
kca.mod
nabalan.mod
netstimd.mod
newleak.mod
nmdanet.mod *
pump.mod *
CellDef.hoc
ctrlfiring_cnt.txt
DA_release.ses
DA_release_final.hoc
DA_release_withdrawal_final.hoc
DA_release_withdrawal_final_noGLU.hoc
firing_cnt.txt
fixnseg.hoc *
mosinit.hoc
screenshot.png
screenshot2.png
                            
TITLE Calcium pump
 

UNITS {
        (molar) = (1/liter)
        (pA) =  (picoamp)
	(mV) =	(millivolt)
        (uS) =  (micromho)
	(mA) =	(milliamp)
	(mM) =	(millimolar)
}


INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}

NEURON {
	SUFFIX capump
	USEION ca READ cai WRITE ica
	RANGE  icapump,icapumpmax,km
 
}


PARAMETER {
        dt    (ms)
        cai   (mM)
        celsius = 35  (degC)
        icapumpmax  = 0.0312  (mA/cm2)
        km = 0.000500         (mM)
                 
}

ASSIGNED { 
          ica     (mA/cm2)
          icapump (mA/cm2)
}


BREAKPOINT {
        icapump = icapumpmax*(1/(1 + km/cai))
	ica = icapump
}

Loading data, please wait...