VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)

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Accession:185330
" ... Here we present a biophysical model of a DA VTA neuron based on 3D morphological reconstruction and electrophysiological data, showing how opiates withdrawal-driven morphological and electrophysiological changes could affect the firing rate and discharge pattern...."
Reference:
1 . Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. Neuroscience 322:195-207 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Addiction;
Implementer(s): Enrico, Paolo [enrico at uniss.it];
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EnricoEtAl2016
README.html
cabal.mod *
cachan.mod
capump.mod *
dop.mod *
hh3.mod
IhDA.mod
kca.mod
nabalan.mod
netstimd.mod
newleak.mod
nmdanet.mod *
pump.mod *
CellDef.hoc
ctrlfiring_cnt.txt
DA_release.ses
DA_release_final.hoc
DA_release_withdrawal_final.hoc
DA_release_withdrawal_final_noGLU.hoc
firing_cnt.txt
fixnseg.hoc *
mosinit.hoc
screenshot.png
screenshot2.png
                            
TITLE Sodium ion accumulation without diffusion

NEURON {
	SUFFIX nabalan
	USEION na READ ina WRITE nai
	RANGE nainit,f
}

UNITS {
	(mM) = (milli/liter)
	(um) = (micron)
	FARADAY = (faraday) (coulomb)
	PI = (pi) (1)
}

PARAMETER {
        nainit = 0.8 (mM) 
        f = 1.00
}

ASSIGNED {
	ina (milliamp/cm2)
	diam (um)
}

STATE {
	nai (mM) <1e-4>
}

BREAKPOINT {
	SOLVE state METHOD sparse
}

INITIAL{
        nai=nainit
}

KINETIC state {
	COMPARTMENT PI*diam*diam/4 {nai}
	~ nai << (-f*ina*PI*diam*(1e4)/(FARADAY))
}


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