Novel Na current with slow de-inactivation (Tsutsui, Oka 2002)

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Accession:18742
The authors found a novel Na current in teleost thalamic nuclei was well described by the m^3 h Hodgkin-Huxley model. The kinetic parameters derived from their experiments (see the reference for details) revealed that the h gate had a large time constant (~100ms at -80 to -50mV). This explains the thalamic neurons long refractory period and the gradual recovery of AP amplitude as the inter spike interval grows.
Reference:
1 . Tsutsui H, Oka Y (2002) Slow removal of Na(+) channel inactivation underlies the temporal filtering property in the teleost thalamic neurons. J Physiol 539:743-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Teleost thalamic neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Axonal Action Potentials; Action Potentials;
Implementer(s): Tsutsui, H ;
Search NeuronDB for information about:  I Na,t; I K; I Sodium; I Potassium;
// this is a modified session file fig7A_VperD.hoc
// that creates a range variable plot graph which
// getline is used to take lines from

objectvar save_window_, rvp_, VvsDgraph
objectvar scene_vector_[9]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
double scene_counter[1]

{
	save_window_ = new Graph(0)
	save_window_.size(-400,600,0,1)
	scene_vector_[8] = save_window_
	{save_window_.view(-100, -80, 2100, 120, 400, 322, 300.48, 200.32)}
	flush_list.append(save_window_)
	save_window_.save_name("flush_list.")
	objectvar rvp_
	rvp_ = new RangeVarPlot("v")
	axon rvp_.begin(0)
	axon rvp_.end(1)
	rvp_.origin(0)
	save_window_.addobject(rvp_, 1, 1, 0.8, 0.9)

	VvsDgraph = save_window_	// for use with getline later
					// to take the Voltage plots
					// for graphing snapshots...
}

objectvar scene_vector_[1]
{doNotify()}

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