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ModelDB is moving. Check out our new site at
https://modeldb.science
.
The corresponding page is
https://modeldb.science/187610
.
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
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Model Information
Model File
Citations
Accession:
187610
"... We examined synaptic connectivity between molecularly defined inhibitory interneurons and CA1 pyramidal cell dendrites using correlative light-electron microscopy and large-volume array tomography. We show that interneurons can be highly selective in their connectivity to specific dendritic branch types and, furthermore, exhibit precisely targeted connectivity to the origin or end of individual branches. Computational simulations indicate that the observed subcellular targeting enables control over the nonlinear integration of synaptic input or the initiation and backpropagation of action potentials in a branchselective manner. Our results demonstrate that connectivity between interneurons and pyramidal cell dendrites is more precise and spatially segregated than previously appreciated, which may be a critical determinant of how inhibition shapes dendritic computation."
Reference:
1 .
Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2016) Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells.
Neuron
89
:1016-30
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I Na,t;
I K;
Gap Junctions:
Receptor(s):
AMPA;
NMDA;
Gaba;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Synaptic Integration;
Implementer(s):
Cembrowski, Mark S [cembrowskim at janelia.hhmi.org];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
AMPA
;
NMDA
;
Gaba
;
I Na,t
;
I K
;
Download the displayed file
/
arrayTomography
README.txt
dists.mod
*
Other models using dists.mod:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
eff.mod
*
Other models using eff.mod:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
exc.mod
id.mod
*
Other models using id.mod:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
inh.mod
kad.mod
*
Other models using kad.mod:
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
kap.mod
*
Other models using kap.mod:
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
kdr.mod
*
Other models using kdr.mod:
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
na3.mod
*
Other models using na3.mod:
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
nmdaSyn.mod
syns.mod
*
Other models using syns.mod:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
activateExcitation.hoc
activateInhibition.hoc
addChannels.hoc
*
Other models using addChannels.hoc:
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
addExcitation.hoc
addVgatInhibition.hoc
channelParameters.hoc
*
Other models using channelParameters.hoc:
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
flagVgatInhibition.hoc
getBranchOrder.hoc
*
Other models using getBranchOrder.hoc:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
idMorph.hoc
inhibitionBiophysics.hoc
initializationAndRun.hoc
*
Other models using initializationAndRun.hoc:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
loadMorph.hoc
*
Other models using loadMorph.hoc:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
mosinit.hoc
*
Other models using mosinit.hoc:
LTP in cerebellar mossy fiber-granule cell synapses (Saftenku 2002)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
naceaxon.nrn
*
Other models using naceaxon.nrn:
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Distance-dependent synaptic strength in CA1 pyramidal neurons (Menon et al. 2013)
processMorph.hoc
*
Other models using processMorph.hoc:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
proofreadMorph.hoc
*
Other models using proofreadMorph.hoc:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
resetNSeg.hoc
*
Other models using resetNSeg.hoc:
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
start.hoc
synHelperScripts.hoc
twinApical.swc
*
Other models using twinApical.swc:
CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
NEURON { SUFFIX dists RANGE mainbif,nSyn,normprim } ASSIGNED { mainbif nSyn normprim }
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