CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)

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Accession:187610
"... We examined synaptic connectivity between molecularly defined inhibitory interneurons and CA1 pyramidal cell dendrites using correlative light-electron microscopy and large-volume array tomography. We show that interneurons can be highly selective in their connectivity to specific dendritic branch types and, furthermore, exhibit precisely targeted connectivity to the origin or end of individual branches. Computational simulations indicate that the observed subcellular targeting enables control over the nonlinear integration of synaptic input or the initiation and backpropagation of action potentials in a branchselective manner. Our results demonstrate that connectivity between interneurons and pyramidal cell dendrites is more precise and spatially segregated than previously appreciated, which may be a critical determinant of how inhibition shapes dendritic computation."
Reference:
1 . Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2016) Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells. Neuron 89:1016-30 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration;
Implementer(s): Cembrowski, Mark S [cembrowskim at janelia.hhmi.org];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; Gaba; I Na,t; I K;
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arrayTomography
README.txt
dists.mod *
eff.mod *
exc.mod
id.mod *
inh.mod
kad.mod *
kap.mod *
kdr.mod *
na3.mod *
nmdaSyn.mod
syns.mod *
activateExcitation.hoc
activateInhibition.hoc
addChannels.hoc *
addExcitation.hoc
addVgatInhibition.hoc
channelParameters.hoc *
flagVgatInhibition.hoc
getBranchOrder.hoc *
idMorph.hoc
inhibitionBiophysics.hoc
initializationAndRun.hoc *
loadMorph.hoc *
mosinit.hoc *
naceaxon.nrn *
processMorph.hoc *
proofreadMorph.hoc *
resetNSeg.hoc *
start.hoc
synHelperScripts.hoc
twinApical.swc *
                            
// CHOOSE FILE NAME
	strdef cellToLoad
	{
		cellToLoad = "twinApical.swc"
	}

// This code is based on the implementation of 
// http://www.neuron.yale.edu/phpbb/viewtopic.php?f=13&t=2272; extended for
// use with an ASCII file emerging from Neurolucida.

	{
		load_file("import3d.hoc")
	}


// This is a dummy template that gets overwritten when the new cell is 
// loaded.  This is included strictly to facilitate the import process.
	begintemplate Cell
	
	public soma, axon, dend, apic
	create soma[1],axon[1],dend[1],apic[1]
	public all,somatic,axonal,basal,apical
	objref all,somatic,axonal,basal,apical
	
	proc init() {
		all = new SectionList()
		somatic = new SectionList()
		axonal = new SectionList()
		basal = new SectionList()
		apical = new SectionList()
	}
	
	endtemplate Cell



// Load the cell.
// $s1 is the morphology name
// On exit, the return object is a Cell instance with the
// morphology specified by the $s1 file

	obfunc mkcell() { localobj import,morph,cell
		cell = new Cell()
		morph = new Import3d_SWC_read()
		morph.input($s1)
		import = new Import3d_GUI(morph,0)
		execute("forall delete_section()",cell)
		import.instantiate(cell)
		return cell
	}
	
	objref cell
	{
		cell = mkcell(cellToLoad)
	}


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