Muscle spindle feedback circuit (Moraud et al, 2016)

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Accession:189786
Here, we developed a computational model of the muscle spindle feedback circuits of the rat ankle that predicts the interactions between Epidural Stimulation and spinal circuit dynamics during gait.
Reference:
1 . Moraud EM, Capogrosso M, Formento E, Wenger N, DiGiovanna J, Courtine G, Micera S (2016) Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury. Neuron 89:814-28 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord motor neuron slow twitch;
Channel(s): I K; I K,Ca; I Na,p; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Sensory processing; Neuromodulation;
Implementer(s): Capogrosso, Marco ; Formento, Emanuele ;
Search NeuronDB for information about:  I Na,p; I K; I K,Ca; I Sodium;
// MUSCLE SPINDLE FEEDBACK CIRCUIT MODEL by 

// Marco Capogrosso and Emanuele Formento

// Published in:
// Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury.
// Moraud EM, Capogrosso M, Formento E, Wenger N, DiGiovanna J, Courtine G, Micera S.
// Neuron. 2016 Feb 17;89(4):814-28. doi: 10.1016/j.neuron.2016.01.009. Epub 2016 Feb 4.


//GENERAL PARAMETERS
{load_file("nrngui.hoc")}
t0 = startsw() // timer

// Parallel Network
objref pc
pc = new ParallelContext()
PcID = pc.id // for python
Nhost = pc.nhost // for python

// Set the number of Cells and Synapses
{xopen("SetNetworkSize.hoc")}

//MCELL
begintemplate M_Cell
{xopen("M_cell.hoc")}
endtemplate M_Cell
//FINE M_CELL

//IAINPUT
begintemplate IA_fiber_stim
{xopen("IA_fiber_nat.hoc")}
endtemplate IA_fiber_stim
//FINE IAINPUT

//IAFIBER
begintemplate IA_fiber
{xopen("Int_Fiber.hoc")}
endtemplate IA_fiber
//IAFIBER

////IAINT
begintemplate IA_Int
{xopen("Int_F.hoc")}
endtemplate IA_Int
////FINE IAINT

//EXINT
begintemplate EXIN_Cell
{xopen("Int_F.hoc")}
endtemplate EXIN_Cell
//EXINT

//IIINPUT
begintemplate II_fiber_stim
{xopen("II_fiber_nat.hoc")}
endtemplate II_fiber_stim
//FINE IIINPUT

//IIFIBER
begintemplate II_fiber
{xopen("Int_Fiber.hoc")}
endtemplate II_fiber
//IIFIBER


//EES
begintemplate EES
{xopen("EES.hoc")}
endtemplate EES
//EES

//NETWORK SET UP
{xopen("NetBuild.hoc")}
//END NETWORK SET UP

//SIMULATION PARAMETERS
celsius=37
dt=0.025
v_init=-70
t1 = startsw() // timer
tstop=1000
{printf("Starting process %d of %d\n", pc.id+1, pc.nhost)}

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