Effects of electric fields on cognitive functions (Migliore et al 2016)

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Accession:190559
The paper discusses the effects induced by an electric field at power lines frequency on neuronal activity during cognitive processes.
Reference:
1 . Migliore R, De Simone G, Leinekugel X, Migliore M (2017) The possible consequences for cognitive functions of external electric fields at power line frequency on hippocampal CA1 pyramidal neurons. Eur J Neurosci 45:1024-1031 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Extracellular Fields; Gamma oscillations; Pattern Recognition; Spatio-temporal Activity Patterns;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]; Migliore, Rosanna [rosanna.migliore at cnr.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I h; Glutamate;
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MiglioreEJN2016
readme.html
distr.mod *
distr2.mod
fzap.mod *
Gfluct.mod
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstimm.mod *
xtrau.mod *
anatscale.hoc *
biophys.hoc
biophysPLAST.hoc
calcd.hoc
calcrxcu.hoc
ef_fig.png
efheader.hoc *
fig1B.hoc
fixnseg.hoc *
freq50.xfm
geo5038804.hoc *
init.hoc
interpxyzu.hoc *
LTDran.hoc
media-st er.xfm
mosinit.hoc
Napical.txt
no_ef_fig.png
Plast.hoc
setnseg.hoc *
setpointersu.hoc *
soma.hoc
synapses.hoc
voltage.ses
zapstimu.hoc
                            
load_file("nrngui.hoc")
cvode_active(1)
load_file("geo5038804.hoc")
numbasal  = 52
numapical = 70
numuser5  = 49
objref stim0, stim1, stim2, stim3, stim4, stim5, ncstim, syn, syn2, nc0, nc1, nc2, nc3, nc4


load_file("biophysPLAST.hoc")
//load_file("synapses.hoc")
load_file("efheader.hoc")



tstop=10000

proc init() {

  t=0

  
  finitialize(Vrest)

	forall {
		v = Vrest
		if(ismembrane("nax") || ismembrane("na3")) {
			ena=55
		}
		if(ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {
			ek=-90
		}
		if(ismembrane("hd")) {
			ehd_hd=-30
		}
	}

	finitialize(Vrest)
	fcurrent()

	forall {
		for(x) {
			if(ismembrane("na3") || ismembrane("nax")) {
				e_pas(x)=v(x)+(ina(x)+ik(x))/g_pas(x)
			}
			if(ismembrane("hd")) {
				e_pas(x)=e_pas(x)+i_hd(x)/g_pas(x)
			}
		}
	}

	/*for i = 0, nsyn-1 {
  		st[i].seed(114)
	}
*/
}

soma {

stim0= new NetStim(.5)
stim0.number=1
stim0.interval=10
stim0.start=10

stim1= new NetStim(.5)
stim1.number=50
stim1.interval=200
stim1.start=500

stim2 = new NetStim(.5)
stim2.number =4
stim2.interval =10
stim2.start =1000

ncstim = new NetCon(stim1, stim2, 0, 0, 0.001)

stim3= new NetStim(.5)
stim3.number =1
stim3.interval =10
stim3.start =1500
}

apical_dendrite[29] {

stim4= new NetStim(0.5)
stim4.number=1
stim4.interval=10
stim4.start=500

stim5= new NetStim(0.5)
stim5.number=1
stim5.interval=10
stim5.start=16000

}


apical_dendrite[27]{
syn= new giada2TBS(.5)
}

nc0= new NetCon(stim0, syn, 0, 0, 10e-3)
nc1 = new NetCon(stim2, syn, 0, 0, 10e-3)
nc2= new NetCon(stim3, syn, 0, 0, 10e-3)

apical_dendrite[29]{
syn2= new giada2TBS(0.5)
}


nc3= new NetCon(stim4, syn2, 0, 0, 1e-3)
nc4= new NetCon(stim5, syn2, 0, 0, 1e-3)

load_file("voltage.ses")
//load_file("heter.ses")
objref vp
vp = save_window_
vp.exec_menu("Keep Lines")
proc sim() {
  vp.erase_all()

	vp.label(0.949956, 0.931495, "no EF", 2, 1, 0, 0, 1)
	vp.label(0.950834, 0.878114, "EF", 2, 1, 0, 0, 2)
  vp.brush(2)
  vp.color(1)
  vp.addvar("", "v(0.5)")
  setstim(50, 6000, 50, 50, 0)
  changefield(100, 90, 90)
  run()

  vp.color(2)
  vp.addexpr("", "v(0.5)")
  setstim(50, 6000, 50, 50, 40)
  changefield(100, 90, 90)
  run()

}


xpanel("electric field sim")
xbutton("Run sims", "sim()")
xpanel(255,672)



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