ModelDB is moving. Check out our new site at The corresponding page is

Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)

 Download zip file 
Help downloading and running models
"Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor cortex layer 5B that project caudally via the medullary pyramids, display distinct class-specific electrophysiological properties in vitro: strong sag with hyperpolarization, lack of adaptation, and a nearly linear frequency-current (FI) relationship. We used our electrophysiological data to produce a pair of large archives of SPI neuron computer models in two model classes: 1. Detailed models with full reconstruction; 2. Simplified models with 6 compartments. We used a PRAXIS and an evolutionary multiobjective optimization (EMO) in sequence to determine ion channel conductances. ..."
1 . Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017) Optimizing computer models of corticospinal neurons to replicate in vitro dynamics. J Neurophysiol 117:148-162 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex M1 L5B pyramidal pyramidal tract GLU cell; Neocortex primary motor area pyramidal layer 5 corticospinal cell;
Channel(s): I A; I h; I_KD; I K,Ca; I L high threshold; I Na,t; I N; Ca pump; Kir;
Gap Junctions:
Simulation Environment: NEURON; Python;
Model Concept(s): Parameter Fitting; Activity Patterns; Active Dendrites; Detailed Neuronal Models; Simplified Models;
Implementer(s): Suter, Benjamin ; Neymotin, Sam [Samuel.Neymotin at]; Dura-Bernal, Salvador [salvadordura at]; Forzano, Ernie ;
Search NeuronDB for information about:  Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I Na,t; I L high threshold; I N; I A; I h; I K,Ca; I_KD; Ca pump; Kir;
cadad.mod *
cal2.mod *
can_mig.mod *
h_kole.mod *
kap_BS.mod *
kBK.mod *
kdmc_BS.mod *
kdr_BS.mod *
misc.mod *
nax_BS.mod *
savedist.mod *
vecst.mod *
PTcell.BS0284.cfg *
PTcell.cfg *
# Set the default behavior, in case people don't have core.autocrlf set.
* text=auto

# Explicitly declare text files you want to always be normalized and converted
# to native line endings on checkout.
*.c text
*.h text

# Declare files that will always have CRLF line endings on checkout.
*.sln text eol=lf

# Denote all files that are truly binary and should not be modified.
*.png binary
*.jpg binary

Loading data, please wait...