Granule cell program files for the paper:
Synaptic integration in a model of cerebellar granule cells.
Gabbiani F, Midtgaard J, Knopfel T.
Institut fur Theoretische Physik, ETH-Honggerberg, Zurich, Switzerland.
J Neurophysiol 1994 Aug;72(2):999-1009
Excerpt from abstract:
1. We have developed a compartmental model of a turtle cerebellar granule
cell consisting of 13 compartments that represent the soma and 4
dendrites. We used this model to investigate the synaptic integration of
mossy fiber inputs in granule cells.
2. The somatic compartment contained six active ionic conductances:
a sodium conductance with fast activation and inactivation kinetics,
gNa; a high-voltage-activated calcium conductance, gCa(HVA); a
delayed potassium conductance, gK(DR); a transient potassium
conductance, gK(A); a slowly relaxing mixed Na+/K+ conductance
activating at hyperpolarized membrane potentials, gH, and a
calcium- and voltage-dependent potassium conductance, gK(Ca). The
kinetics of these conductances was derived from electrophysiological
studies in a variety of preparations, including turtle and rat granule
3. In the soma, dynamics of intracellular free Ca2+ was modeled
by incorporation of a Na+/Ca2+ exchanger, radial diffusion, and binding
sites for Ca2+.
4. The model of the turtle granule cell exhibited depolarization-induced
action potential firing with properties closely resembling those seen
with intracellular recordings in turtle granule cells in vitro.
... please see the paper for 5 more summary paragraphs.
The model files are configured to reproduce results from the first two
figures when auto-launched. Press a figure button in the simulation
control box to see that figure.
See the paper for additional detailed studies that examine the role
of NMDA receptors in temporal summation of excitatory synaptic
potentials and GABAA receptors role in coincidence detection; Golgi
cell inhibition on mossy fiber to granule cell transmission and more...