Synaptic integration in a model of granule cells (Gabbiani et al 1994)

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Accession:19591
We have developed a compartmental model of a turtle cerebellar granule cell consisting of 13 compartments that represent the soma and 4 dendrites. We used this model to investigate the synaptic integration of mossy fiber inputs in granule cells. See reference or abstract at PubMed link below for more information.
Reference:
1 . Gabbiani F, Midtgaard J, Knöpfel T (1994) Synaptic integration in a model of cerebellar granule cells. J Neurophysiol 72:999-1009 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I Na,t; I L high threshold; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Coincidence Detection; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Gabbiani, F;
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I K; I h; I K,Ca;
// fig1a.hoc generates figures 1A and 1B

tstop = 2000

IClamp[0].dur=1000	// length of current injection
IClamp[0].del=100	// delay before injection

//	create graph
xopen("vgraph.ses")	// created by saving a volt graph
ccgraph.exec_menu("Keep Lines")

// use low resolution for speed
steps_per_ms = 4
dt = .25

// run simulation with a few injections

for i=0,3 {

	if (i==0) {IClamp[0].amp = 0.01}
	if (i==1) {IClamp[0].amp = -0.01}
	if (i==2) {IClamp[0].amp = -0.02}
	if (i==3) {IClamp[0].amp = -0.03}

	init()
	run()
}
ccgraph.exec_menu("View = plot")
ccgraph.label(.45,.95,"Figure 1 A")



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