Synaptic integration in a model of granule cells (Gabbiani et al 1994)

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Accession:19591
We have developed a compartmental model of a turtle cerebellar granule cell consisting of 13 compartments that represent the soma and 4 dendrites. We used this model to investigate the synaptic integration of mossy fiber inputs in granule cells. See reference or abstract at PubMed link below for more information.
Reference:
1 . Gabbiani F, Midtgaard J, Knöpfel T (1994) Synaptic integration in a model of cerebellar granule cells. J Neurophysiol 72:999-1009 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule cell;
Channel(s): I Na,t; I L high threshold; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Coincidence Detection; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Gabbiani, F;
Search NeuronDB for information about:  Cerebellum interneuron granule cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I K; I h; I K,Ca;
/*----------------------------------------------------------------
  %W%                     %G%

  turtle granule cell with 4 dendrites new electrical model.

----------------------------------------------------------------*/


global_ra = 100

         					/* create sections */
create    soma, dendrite[4], bulb[4]




proc geometry() { local i, j

						/* soma geometry */
    soma {
        nseg = 1
        pt3dclear()
        for j = 1, fscan() {
            pt3dadd(fscan(),fscan(),fscan(),fscan())
        }
    }

    for i = 0,3 {
        dendrite[i] {
            nseg = fscan()
            pt3dclear()
            for j = 1, fscan() {
                pt3dadd(fscan(),fscan(),fscan(),fscan())
            }
        }
    }

    for i = 0,3 {
        bulb[i] {
            nseg = fscan()
            pt3dclear()
            for j = 1, fscan() {
                pt3dadd(fscan(),fscan(),fscan(),fscan())
            }
        }
    }

					/* connect dendrites */
    for i = 0,3 {
      soma connect dendrite[i] (0), 1
    }

					/* connect bulbs */
    for i = 0,3 {
      dendrite[i] connect bulb[i] (0), 1
    }

}

geometry()


SOMA COORDINATES AND DIAMETERS:

    2
    0      0  0  6.76
    14.55  0  0  6.76


DENDRITE COORDINATES AND DIAMETERS:

    2 2
    5      0  0  1.24
    93.1   0  0  1.24

    2 2
    -5      0  0  1.24
    -93.1   0  0  1.24

    2 2
    0   5      0  1.24
    0   93.1   0  1.24

    2 2
    0  -5      0  1.24
    0  -93.1   0  1.24


BULB COORDINATES AND DIAMETERS:

    1 2
    93.1   0  0  3.6
    100.3  0  0  3.6

    1 2
    -93.1   0  0  3.6
    -100.3  0  0  3.6

    1 2
    0   93.1   0  3.6
    0   100.3  0  3.6

    1 2
    0  -93.1   0  3.6
    0  -100.3  0  3.6

/*----------------------------------------------------------------*/
proc geometry() { 

	/* NULL geometry procedure: keeps the user from
	calling the geometry procedure in isolation. */

    printf("\nYou must re-read the entire geometry\n")
    printf("file to execute geometry().\n\n")
}

forall Ra = global_ra

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