Signal integration in a CA1 pyramidal cell (Graham 2001)

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Accession:19746
This model investigates signal integration in the dendritic tree of a hippocampal CA1 pyramidal cell when different combinations of active channels are present in the tree (Graham, 2001)
Reference:
1 . Graham BP (2001) Pattern recognition in a compartmental model of a CA1 pyramidal neuron. Network 12:473-92 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Potassium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites;
Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Potassium;
COMMENT
A synaptic current with dual exponential function conductance defined by
        i = g * (v - e)      i(nanoamps), g(micromhos);
        where
         g = 0 for t < onset and
         g = gmax*((tau1*tau2)/(tau1-tau2)) *
                             (exp(-(t-onset)/tau1)-exp(-(t-onset)/tau2))
         for t > onset (tau1 and tau2 are fast and slow time constants)
BPG 14-3-98
ENDCOMMENT
					       
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	POINT_PROCESS DESynapse
	RANGE onset, tau1, tau2, gmax, e, i, g
	NONSPECIFIC_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(umho) = (micromho)
}

PARAMETER {
	onset=0 (ms)
	tau1=.2 (ms)	<1e-3,1e6>
	tau2=2 (ms)	<1e-3,1e6>
	gmax=0 	(umho)	<0,1e9>
	e=0	(mV)
	v	(mV)
}

ASSIGNED { i (nA)  g (umho)}

BREAKPOINT {
	g = gmax*((tau1*tau2)/(tau1-tau2))*duale((t-onset)/tau1,(t-onset)/tau2)
	i = g*(v - e)
}

FUNCTION duale(x,y) {
	if (x < 0 || y < 0) {
		duale = 0
	}else{
		duale = exp(-x) - exp(-y)
	}
}

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