Signal integration in a CA1 pyramidal cell (Graham 2001)

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Accession:19746
This model investigates signal integration in the dendritic tree of a hippocampal CA1 pyramidal cell when different combinations of active channels are present in the tree (Graham, 2001)
Reference:
1 . Graham BP (2001) Pattern recognition in a compartmental model of a CA1 pyramidal neuron. Network 12:473-92 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Potassium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites;
Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Potassium;
objectvar save_window_, rvp_
objectvar scene_vector_[3]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{
xpanel("Active Channels", 0)
xlabel("Sodium Channels")
gbarINaP = 5e-06
xvalue("Na(P) gbar","gbarINaP", 1,"", 0, 0 )
INaP_half = -49
xvalue("Na(P) Vhalf","INaP_half", 1,"", 0, 0 )
xlabel("Potassium Channels")
global_gka = 0.0002
xvalue("K(A) gbar","global_gka", 1,"", 0, 0 )
dfacA = 100
xvalue("K(A) dist. fact.","dfacA", 1,"", 0, 0 )
thminKA = 2
xvalue("K(A) tau(inact)","thminKA", 1,"", 0, 0 )
xlabel("Nonspecific Cation Channels")
global_gh = 3e-05
xvalue("NC(H) gbar","global_gh", 1,"", 0, 0 )
dfacH = 80
xvalue("NC(H) dist. fact.","dfacH", 1,"", 0, 0 )
tcH = 50
xvalue("NC(H) tau(act)","tcH", 1,"", 0, 0 )
xlabel("Calcium Channels")
gbarICaG = 0.0005
xvalue("Ca(G) gbar","gbarICaG", 1,"", 0, 0 )
tcCaG = 1
xvalue("Ca(G) tau(inact)","tcCaG", 1,"", 0, 0 )
xlabel("Control")
xbutton("Update","adjust_apical()")
xpanel(339,259)
}
{
xpanel("Excitatory Synapses", 0)
nsyn = 200
xvalue("Number of synapses","nsyn", 1,"", 0, 0 )
DE_gmax = 0.0007
xvalue("Synaptic conductance (nS)","DE_gmax", 1,"", 0, 0 )
NMDA_frac = 0.05
xvalue("NMDA fraction","NMDA_frac", 1,"", 0, 0 )
jitter_time = 0
xvalue("Temporal jitter (msec)","jitter_time", 1,"", 0, 0 )
quantal_cv = 0
xvalue("Quantal variance (CV)","quantal_cv", 1,"", 0, 0 )
gsc_flag = 1
xvalue("Conductance scaling","gsc_flag", 1,"", 0, 0 )
my_seed = 10
xvalue("Random seed","my_seed", 1,"", 0, 0 )
xbutton("Update synapses","creatensynDE(layer_SR, nsyn, my_seed)")
xpanel(4,454)
}
{
xpanel("RunControl", 0)
v_init = -65
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 100
xvalue("t","t", 2 )
tstop = 100
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.025
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 40
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 15
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(4,103)
}
{
save_window_ = new Graph(0)
save_window_.size(0,100,-65,-7)
scene_vector_[2] = save_window_
{save_window_.view(0, -65, 100, 58, 326, 20, 300.48, 201.28)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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