Signal integration in a CA1 pyramidal cell (Graham 2001)

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Accession:19746
This model investigates signal integration in the dendritic tree of a hippocampal CA1 pyramidal cell when different combinations of active channels are present in the tree (Graham, 2001)
Reference:
1 . Graham BP (2001) Pattern recognition in a compartmental model of a CA1 pyramidal neuron. Network 12:473-92 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Potassium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites;
Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Potassium;
/* Global constants for CA1 neuron simulations
   Version for Network paper (BPG 26-11-02)
*/

// Run control
my_print = 0
my_seed = 16
nsyn = 200  // number of synapses

// Passive properties
celsius = 35
Rm = 30000 /* Ohm cm^2 */
Cm = 1.0 /* uF cm^-2 */
Ri = 200 /* Ohm cm */
E_pas = -65 /* mV */

// Spines
spine_flag = 0
sneck_diam = 0.1 /* um */
sneck_len = 0.5 /* um */
shead_diam = 0.25 /* um */
shead_len = 0.5 /* um */

// Synapse
syn_gmax = 0.006 /* mS - reference value for AMPA-only synapse*/
DE_gmax = 0.0007 /* mS */
NMDA_frac = 0.05 /* fraction of max g is NMDA */
DE_tau1 = 0.2 /* msec */
DE_tau2 = 2.0 /* msec */
NMDA_tau1 = 0.66 /* msec */
NMDA_tau2 = 80.0 /* msec */
DE_Erev = 0 /* mV */
DE_onset = 0 /* msec */
jitter_time = 0 /* msec */
quantal_cv = 0 /* quantal noise CV */
// synaptic conductance scaling
gsc_flag = 1
gsc_slope = 0.02088

// Active properties
gbarINaP = 0.000005
INaP_half = -49
global_gka = 0.0002
dfacA = 100
thminKA = 2
global_gh = 0.00003
dfacH = 80
tcH = 50
gbarICaG = 0.0005
tcCaG = 1

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