Signal integration in a CA1 pyramidal cell (Graham 2001)

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Accession:19746
This model investigates signal integration in the dendritic tree of a hippocampal CA1 pyramidal cell when different combinations of active channels are present in the tree (Graham, 2001)
Reference:
1 . Graham BP (2001) Pattern recognition in a compartmental model of a CA1 pyramidal neuron. Network 12:473-92 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Potassium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites;
Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Potassium;
/* run_CA1.hoc
   Construct and simulate Major's CA1 pyramidal cell.
   A fixed number of synapses are added to stratum radiatum.
   Version for Network paper (BPG 26-11-02)
*/

xopen("$(NEURONHOME)/lib/hoc/noload.hoc")
//load_proc("nrnmainmenu")

xopen("globals.hoc")
xopen("cell_pass.hoc")
xopen("layers.hoc")
xopen("synapse.hoc")
xopen("memb_CA1.hoc")
xopen("xmenusyn.hoc")


// Somatic spiking (channels from Bernander et al)
//soma {insert BKDNaDR gnabar_BKDNaDR=0.1 gkbar_BKDNaDR=0.06}

// Lipowsky et al's INaP
insert_Na()

// Warman et al's ICaG
insert_Ca()

// Migliore et al's IKA
insert_KA()

// Borg-Graham's IH
insert_H()

adjust_apical()
// balance IH at rest of -65mV
forall {if (ismembrane("pas")) {e_pas=-70}}  

// creates n dual exponential synapses that produce a single EPSC
// creatensynDE(SectionList object, no. of synapses, random seed)
creatensynDE(layer_SR, nsyn, my_seed)

nrnmainmenu()
//xmenumem()
//xmenusyn()
xopen("fixed_syn.ses")

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