Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Feedforward inhibition in pyramidal cells (Ferrante & Ascoli 2015)
Download zip file
Help downloading and running models
Versions on GitHub
"Feedforward inhibition (FFI) enables pyramidal cells in area CA1 of the hippocampus (CA1PCs) to remain easily excitable while faithfully representing a broad range of excitatory inputs without quickly saturating. Despite the cortical ubiquity of FFI, its specific function is not completely understood. FFI in CA1PCs is mediated by two physiologically and morphologically distinct GABAergic interneurons: fast-spiking, perisomatic-targeting basket cells and regular-spiking, dendritic-targeting bistratified cells. These two FFI pathways might create layer-specific computational sub-domains within the same CA1PC, but teasing apart their specific contributions remains experimentally challenging. We implemented a biophysically realistic model of CA1PCs using 40 digitally reconstructed morphologies and constraining synaptic numbers, locations, amplitude, and kinetics with available experimental data. ..."
Ferrante M, Ascoli GA (2015) Distinct and synergistic feedforward inhibition of pyramidal cells by basket and bistratified interneurons.
Front Cell Neurosci
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal cell;
Hippocampus CA1 bistratified cell;
Hippocampus CA1 basket cell;
Ferrante, Michele [mferr133 at bu.edu];
for information about:
Hippocampus CA1 pyramidal cell
File not selected
<- Select file from this column.
Loading data, please wait...