Infraslow intrinsic rhythmogenesis in a subset of AOB projection neurons (Gorin et al 2016)

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Accession:217783
We investigated patterns of spontaneous neuronal activity in mouse accessory olfactory bulb mitral cells, the direct neural link between vomeronasal sensory input and limbic output. Both in vitro and in vivo, we identify a subpopulation of mitral cells that exhibit slow stereotypical rhythmic discharge. In intrinsically rhythmogenic neurons, these periodic activity patterns are maintained in absence of fast synaptic drive. The physiological mechanism underlying mitral cell autorhythmicity involves cyclic activation of three interdependent ionic conductances: subthreshold persistent Na(+) current, R-type Ca(2+) current, and Ca(2+)-activated big conductance K(+) current. Together, the interplay of these distinct conductances triggers infraslow intrinsic oscillations with remarkable periodicity, a default output state likely to affect sensory processing in limbic circuits. The model reproduces the intrinsic firing in a reconstructed single AOB mitral cell with ion channels kinetics fitted to experimental measurements of their steady state and time course.
Reference:
1 . Gorin M, Tsitoura C, Kahan A, Watznauer K, Drose DR, Arts M, Mathar R, O'Connor S, Hanganu-Opatz IL, Ben-Shaul Y, Spehr M (2016) Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons. J Neurosci 36:3127-44 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb (accessory) mitral cell;
Channel(s): I Potassium; I Na,p; I Calcium; I Na,t; I K,Ca; I A; I K; I R;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Sensory processing; Oscillations; Olfaction;
Implementer(s): O'Connor, Simon [simon.oconnor at btinternet.com];
Search NeuronDB for information about:  I Na,p; I Na,t; I A; I K; I K,Ca; I Calcium; I Potassium; I R;
COMMENT

   **************************************************
   File generated by: neuroConstruct v1.7.1 
   **************************************************

   This file holds the implementation in NEURON of the Cell Mechanism:
   LeakConductance (Type: Channel mechanism, Model: Template based ChannelML file)

   with parameters: 
   /channelml/@units = Physiological Units 
   /channelml/notes = ChannelML file containing a single Channel description 
   /channelml/channel_type/@name = LeakConductance 
   /channelml/channel_type/@density = yes 
   /channelml/channel_type/status/@value = stable 
   /channelml/channel_type/notes = Simple example of a leak/passive conductance. Note: for GENESIS cells with a single leak conductance,         it is better to use the Rm and Em variab ... 
   /channelml/channel_type/current_voltage_relation/@cond_law = ohmic 
   /channelml/channel_type/current_voltage_relation/@ion = non_specific 
   /channelml/channel_type/current_voltage_relation/@default_erev = -74.1 
   /channelml/channel_type/current_voltage_relation/@default_gmax = 0.3 

// File from which this was generated: /home/Simon/NML2_Test/AOB_MC_neuroConstruct/cellMechanisms/LeakConductance/LeakConductance.xml

// XSL file with mapping to simulator: /home/Simon/NML2_Test/AOB_MC_neuroConstruct/cellMechanisms/LeakConductance/ChannelML_v1.8.1_NEURONmod.xsl

ENDCOMMENT


?  This is a NEURON mod file generated from a ChannelML file

?  Unit system of original ChannelML file: Physiological Units

COMMENT
    ChannelML file containing a single Channel description
ENDCOMMENT

TITLE Channel: LeakConductance

COMMENT
    Simple example of a leak/passive conductance. Note: for GENESIS cells with a single leak conductance,
        it is better to use the Rm and Em variables for a passive current.
ENDCOMMENT


UNITS {
    (mA) = (milliamp)
    (mV) = (millivolt)
    (S) = (siemens)
    (um) = (micrometer)
    (molar) = (1/liter)
    (mM) = (millimolar)
    (l) = (liter)
}


    
NEURON {
      

    SUFFIX LeakConductance
    ? A non specific current is present
    RANGE e
    NONSPECIFIC_CURRENT i
    
    RANGE gmax, gion
    
}

PARAMETER { 
      

    gmax = 0.0003 (S/cm2)  ? default value, should be overwritten when conductance placed on cell
    
    e = -74.1 (mV) ? default value, should be overwritten when conductance placed on cell
    
}



ASSIGNED {
      

    v (mV)
        
    i (mA/cm2)
        
}

BREAKPOINT { 
    i = gmax*(v - e) 
        

}



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