Regulation of motoneuron excitability by KCNQ/Kv7 modulators (Lombardo & Harrington 2016)

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Accession:217882
" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Reference:
1 . Lombardo J, Harrington MA (2016) Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels. J Neurophysiol 116:2114-2124 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Potassium; I K; I Na,t; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s): Lombardo, Joseph [josslomb at gmail.com];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,t; I K; I M; I Potassium;
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LombardoHarrington2016
readme.html
Gfluctdv.mod *
ghchan.mod *
kca2.mod *
kdrRL.mod *
Km.mod *
kv1_gp.mod
L_Ca.mod *
mAHP.mod *
na3n.mod
na3rp.mod *
naps.mod *
napsi.mod *
buttons.png
ctrl.png
FR3cablepas.hoc
FRMot3dendNaHH.hoc
gKm0.png
GraphicsKmModulators.hoc
ModifiedFRMotoneuron.hoc
mosinit.hoc
retigabine.png
standard_0.hoc
Tools.ses
XE991.png
                            
// FRMotoneuron.hoc
// Base code to create motoneuron and CC & VC ramp
// Expected to be executed from some other directory, with THIS file location and its 
// helpers in the directory "codeloc"

{xopen("FR3cablepas.hoc")}

access soma
insert na3rp
insert naps
insert kdrRL
gMax_kdrRL=0.1
insert mAHP
gkcamax_mAHP=0.01
gcamax_mAHP=1.5e-5
eca=80
insert gh

access axonhillock
insert na3rp
insert naps
insert kdrRL
gMax_kdrRL=0.15

access is
insert na3rp
insert naps
insert kdrRL
gMax_kdrRL=0.6

forsec dend{
insert gh
insert na3rp
insert naps
insert kdrRL
insert kca2
insert L_Ca
insert mAHP
gcamax_mAHP(0:0.1)=1.5e-5:1.5e-5
gcamax_mAHP(0.1:1)=0:0
gkcamax_mAHP(0:0.1)=0.004:0.004
gkcamax_mAHP(0.1:1)=0:0
gMax_kdrRL(0:1)=0.07:0
g_kca2(0:0.3)=0:0
g_kca2(0.3:0.6)=3.8e-4:3.8e-4
g_kca2(0.6:1)=0:0
gcabar_L_Ca (0:0.3)=0:0
gcabar_L_Ca(0.3:0.6)=4e-4:4e-4
gcabar_L_Ca (0.6:1)=0:0
depth2_kca2=1000
taur2_kca2=425
depth1_kca2=0.1
taur1_kca2=20
eca=80
}

access soma

theta_m_L_Ca=-40
tau_m_L_Ca=60







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