CA1 pyr cell: Inhibitory modulation of spatial selectivity+phase precession (Grienberger et al 2017)

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Accession:225080
Spatially uniform synaptic inhibition enhances spatial selectivity and temporal coding in CA1 place cells by suppressing broad out-of-field excitation.
Reference:
1 . Grienberger C, Milstein AD, Bittner KC, Romani S, Magee JC (2017) Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells. Nat Neurosci 20:417-426 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Place cell/field; Synaptic Integration; Short-term Synaptic Plasticity; Spatial Navigation; Feature selectivity;
Implementer(s): Milstein, Aaron D. [aaronmil at stanford.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; NMDA;
/
GrienbergerEtAl2017
morphologies
readme.txt
ampa_kin.mod *
exp2EPSC.mod
exp2EPSG.mod
exp2EPSG_NMDA.mod
gaba_a_kin.mod *
h.mod
kad.mod *
kap.mod *
kdr.mod *
km2.mod
nas.mod
nax.mod
nmda_kin2.mod
nmda_kin3.mod
nmda_kin5.mod *
pr.mod *
vecevent.mod *
batch_EPSP_attenuation.sh
batch_place_cell_r_inp.sh
batch_place_cell_record_i_syn.sh
batch_place_cell_single_compartment.sh
batch_place_cell_subtr_inh.sh
batch_place_cell_subtr_inh_shifted.sh
batch_place_cell_subtr_inh_vclamp.sh
batch_process_i_syn_files.sh
batch_rinp.sh
batch_spine_attenuation_ratio.sh
build_expected_EPSP_reference.sh
build_expected_EPSP_reference_controller.py
build_expected_EPSP_reference_engine.py
consolidate_i_syn_files.py
consolidate_tracked_spine_data.py
fit_parameter_exponential_distribution.py
function_lib.py
optimize_AMPA_KIN.py
optimize_dendritic_excitability_020416.py
optimize_GABA_A_KIN.py
optimize_NMDA_KIN2.py
parallel_branch_cooperativity.sh
parallel_branch_cooperativity_no_nmda.sh
parallel_clustered_branch_cooperativity_nmda_controller_110315.py
parallel_clustered_branch_cooperativity_nmda_engine_110315.py
parallel_EPSP_attenuation_controller.py
parallel_EPSP_attenuation_engine.py
parallel_EPSP_i_attenuation_controller.py
parallel_EPSP_i_attenuation_engine.py
parallel_expected_EPSP_controller.py
parallel_expected_EPSP_engine.py
parallel_optimize_branch_cooperativity.sh
parallel_optimize_branch_cooperativity_nmda_kin3_controller.py
parallel_optimize_branch_cooperativity_nmda_kin3_engine.py
parallel_optimize_EPSP_amp_controller.py
parallel_optimize_EPSP_amp_engine.py
parallel_optimize_pr.sh
parallel_optimize_pr_controller_020116.py
parallel_optimize_pr_engine_020116.py
parallel_rinp_controller.py
parallel_rinp_engine.py
parallel_spine_attenuation_ratio_controller.py
parallel_spine_attenuation_ratio_engine.py
plot_channel_distributions.py
plot_NMDAR_kinetics.py
plot_results.py
plot_spine_traces.py
plot_synaptic_conductance_facilitation.py
process_i_syn_files.py
record_bAP_attenuation.py
simulate_place_cell_no_precession.py
simulate_place_cell_single_compartment.py
simulate_place_cell_single_compartment_no_nmda.py
simulate_place_cell_subtr_inh.py
simulate_place_cell_subtr_inh_add_noise.py
simulate_place_cell_subtr_inh_add_noise_no_na.py
simulate_place_cell_subtr_inh_no_na.py
simulate_place_cell_subtr_inh_no_nmda_no_na.py
simulate_place_cell_subtr_inh_r_inp.py
simulate_place_cell_subtr_inh_rec_i_syn.py
simulate_place_cell_subtr_inh_shifted.py
simulate_place_cell_subtr_inh_silent.py
simulate_place_cell_subtr_inh_vclamp.py
specify_cells.py
                            
__author__ = 'milsteina'
from function_lib import *

target_file_list = ['output051120161734-pid45981-seed3-e3200-i500-mod_inh0-track_spines_2.5_90',
 'output051120161734-pid45996-seed3-e3200-i500-mod_inh0-track_spines_2.5_91',
 'output051120161734-pid45994-seed3-e3200-i500-mod_inh0-track_spines_2.5_92',
 'output051120161734-pid101565-seed3-e3200-i500-mod_inh0-track_spines_2.5_93',
 'output051120161734-pid17557-seed3-e3200-i500-mod_inh0-track_spines_2.5_94',
 'output051120161734-pid17569-seed3-e3200-i500-mod_inh0-track_spines_2.5_95',
 'output051120161734-pid11739-seed3-e3200-i500-mod_inh0-track_spines_2.5_96',
 'output051120161734-pid11750-seed3-e3200-i500-mod_inh0-track_spines_2.5_97',
 'output051120161734-pid32298-seed3-e3200-i500-mod_inh0-track_spines_2.5_98',
 'output051120161734-pid43234-seed3-e3200-i500-mod_inh0-track_spines_2.5_99',
 'output051120161734-pid129036-seed3-e3200-i500-mod_inh1-track_spines_2.5_100',
 'output051120161734-pid1542-seed3-e3200-i500-mod_inh1-track_spines_2.5_101',
 'output051120161734-pid14536-seed3-e3200-i500-mod_inh1-track_spines_2.5_102',
 'output051120161735-pid46556-seed3-e3200-i500-mod_inh1-track_spines_2.5_103',
 'output051120161734-pid46495-seed3-e3200-i500-mod_inh1-track_spines_2.5_104',
 'output051120161734-pid1330-seed3-e3200-i500-mod_inh1-track_spines_2.5_105',
 'output051120161734-pid1326-seed3-e3200-i500-mod_inh1-track_spines_2.5_106',
 'output051120161734-pid1329-seed3-e3200-i500-mod_inh1-track_spines_2.5_107',
 'output051120161734-pid17608-seed3-e3200-i500-mod_inh1-track_spines_2.5_108',
 'output051120161734-pid41419-seed3-e3200-i500-mod_inh1-track_spines_2.5_109',
 'output051120161734-pid66514-seed3-e3200-i500-mod_inh2-track_spines_2.5_110',
 'output051120161734-pid32344-seed3-e3200-i500-mod_inh2-track_spines_2.5_111',
 'output051120161734-pid19638-seed3-e3200-i500-mod_inh2-track_spines_2.5_112',
 'output051120161734-pid46521-seed3-e3200-i500-mod_inh2-track_spines_2.5_113',
 'output051120161735-pid35835-seed3-e3200-i500-mod_inh2-track_spines_2.5_114',
 'output051120161735-pid35834-seed3-e3200-i500-mod_inh2-track_spines_2.5_115',
 'output051120161735-pid29594-seed3-e3200-i500-mod_inh2-track_spines_2.5_116',
 'output051120161735-pid29595-seed3-e3200-i500-mod_inh2-track_spines_2.5_117',
 'output051120161735-pid29598-seed3-e3200-i500-mod_inh2-track_spines_2.5_118',
 'output051120161735-pid37414-seed3-e3200-i500-mod_inh2-track_spines_2.5_119']

i_AMPA_files = ['output051120161751-pid46910-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_90',
 'output051120161751-pid46907-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_91',
 'output051120161819-pid115964-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_92',
 'output051120161819-pid115957-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_93',
 'output051120161819-pid115961-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_94',
 'output051120161819-pid12237-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_95',
 'output051120161931-pid40712-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_96',
 'output051120161932-pid23562-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_97',
 'output051120161933-pid14193-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_98',
 'output051120161933-pid44423-seed3-e3200-i500-mod_inh0-i_AMPA_2.5_99',
 'output051120161934-pid23372-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_100',
 'output051120161934-pid47736-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_101',
 'output051120161934-pid28605-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_102',
 'output051120161934-pid10044-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_103',
 'output051120161934-pid44262-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_104',
 'output051120161934-pid33775-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_105',
 'output051120161934-pid44467-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_106',
 'output051120161935-pid21165-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_107',
 'output051120161936-pid18911-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_108',
 'output051120161936-pid16108-seed3-e3200-i500-mod_inh1-i_AMPA_2.5_109',
 'output051120161940-pid44407-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_110',
 'output051120161940-pid31191-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_111',
 'output051120161940-pid34277-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_112',
 'output051120161940-pid34277-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_113',
 'output051120161940-pid23581-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_114',
 'output051120161940-pid10663-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_115',
 'output051120161940-pid14437-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_116',
 'output051120161940-pid44598-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_117',
 'output051120161941-pid45082-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_118',
 'output051120161941-pid34716-seed3-e3200-i500-mod_inh2-i_AMPA_2.5_119']

i_NMDA_files = ['output051120161933-pid14228-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_90',
 'output051120161933-pid22862-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_91',
 'output051120161933-pid41477-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_92',
 'output051120161933-pid28484-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_93',
 'output051120161933-pid11674-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_94',
 'output051120161933-pid40641-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_95',
 'output051120161934-pid18119-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_96',
 'output051120161934-pid31062-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_97',
 'output051120161934-pid42956-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_98',
 'output051120161934-pid29421-seed3-e3200-i500-mod_inh0-i_NMDA_2.5_99',
 'output051120161936-pid33368-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_100',
 'output051120161936-pid36297-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_101',
 'output051120161936-pid15330-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_102',
 'output051120161937-pid11508-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_103',
 'output051120161937-pid22929-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_104',
 'output051120161938-pid34221-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_105',
 'output051120161939-pid23426-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_106',
 'output051120161939-pid23474-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_107',
 'output051120161939-pid67043-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_108',
 'output051120161940-pid28825-seed3-e3200-i500-mod_inh1-i_NMDA_2.5_109',
 'output051120161941-pid28603-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_110',
 'output051120161941-pid44449-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_111',
 'output051120161941-pid27039-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_112',
 'output051120161942-pid37966-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_113',
 'output051120161942-pid44890-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_114',
 'output051120161942-pid24988-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_115',
 'output051120161943-pid23250-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_116',
 'output051120161944-pid44622-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_117',
 'output051120162107-pid10070-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_118',
 'output051120162107-pid24992-seed3-e3200-i500-mod_inh2-i_NMDA_2.5_119']

index_list = []
key_list = []
target_filename = target_file_list[0]
with h5py.File(data_dir+target_filename+'.hdf5', 'r') as target_file:
    target_trial = target_file.itervalues().next()
    for target_rec in target_trial['rec'].itervalues():
        if 'description' in target_rec.attrs and target_rec.attrs['description'] == 'spine_vm':
            index_list.append(target_rec.attrs['index'])
with h5py.File(data_dir+i_AMPA_files[0]+'.hdf5', 'r') as source_file:
    source_trial = source_file.itervalues().next()
    for source_key in source_trial['rec']:
        if ('index' in source_trial['rec'][source_key].attrs) and \
                (source_trial['rec'][source_key].attrs['index'] in index_list):
            key_list.append(source_key)
for i, target_filename in enumerate(target_file_list):
    with h5py.File(data_dir + target_filename + '.hdf5', 'a') as target_file:
        for trial_key in target_file:
            for source_file_list in i_AMPA_files, i_NMDA_files:
                with h5py.File(data_dir+source_file_list[i]+'.hdf5', 'r') as source_file:
                    target_key_int = len(target_file[trial_key]['rec'])
                    for source_key in key_list:
                        target_file.copy(source_file[trial_key]['rec'][source_key], target_file[trial_key]['rec'],
                                         str(target_key_int))
                        target_key_int += 1

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