L5 PFC pyramidal neurons (Papoutsi et al. 2017)

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Accession:230811
" ... Here, we use a modeling approach to investigate whether and how the morphology of the basal tree mediates the functional output of neurons. We implemented 57 basal tree morphologies of layer 5 prefrontal pyramidal neurons of the rat and identified morphological types which were characterized by different response features, forming distinct functional types. These types were robust to a wide range of manipulations (distribution of active ionic mechanisms, NMDA conductance, somatic and apical tree morphology or the number of activated synapses) and supported different temporal coding schemes at both the single neuron and the microcircuit level. We predict that the basal tree morphological diversity among neurons of the same class mediates their segregation into distinct functional pathways. ..."
Reference:
1 . Papoutsi A, Kastellakis G, Poirazi P (2017) Basal tree complexity shapes functional pathways in the prefrontal cortex. J Neurophysiol 118:1970-1983 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s):
Channel(s): I A; I h; I L high threshold; I T low threshold; I N; I R; I K,Ca; I_AHP; I_Ks; I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA; GabaB;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Detailed Neuronal Models;
Implementer(s): Papoutsi, Athanasia [athpapoutsi at gmail.com];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca; I_Ks; I R; I_AHP; Gaba; Glutamate;
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PapoutsiEtAl2017
mod_files
ampa.mod
ampain.mod
cad.mod
cal.mod
can.mod *
car.mod *
cat.mod *
gabaa.mod *
gabaain.mod
gabab.mod *
h.mod
iks_in.mod
kadist.mod *
kca.mod *
kct.mod *
kd.mod
kdr_in.mod
kdrD.mod *
naf.mod
naf_in.mod
nap.mod *
NMDA.mod
NMDA_syn.mod
vecstim.mod
                            
TITLE N-type calcium channel 
: used in somatic and dendritic regions 
: After Borg 
:  Updated by Maria Markaki  03/12/03

NEURON {
	SUFFIX can
	USEION ca READ cai, eca WRITE ica 
        RANGE gcalbar, ica, po
	GLOBAL hinf, minf, s_inf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) =	(millimolar)
	FARADAY = (faraday) (coulomb)
	R = (k-mole) (joule/degC)
}

PARAMETER {           :parameters that can be entered when function is called in cell-setup 
	gcalbar = 0   (mho/cm2)  : initialized conductance
  	ki     = 0.025  (mM)            :test middle point of inactivation fct
  :	ki     = 0.01  (mM)            :test middle point of inactivation fct
	zetam = -3.4
	zetah = 2
	vhalfm =-21 (mV)
	vhalfh =-40 (mV)
	tm0=1.5(ms)
	th0=75(ms)
:	taumin  = 10    (ms)            : minimal value of the time cst
	taumin  = 2    (ms)            : minimal value of the time cst
}



ASSIGNED {     : parameters needed to solve DE
	v            (mV)
	celsius      (degC)
	ica          (mA/cm2)
	po
	cai          (mM)       :5e-5 initial internal Ca++ concentration
	eca             (mV)
        minf
        hinf
	s_inf
}


FUNCTION h2(cai(mM)) {
	h2 = ki/(ki+cai)
}



STATE {	
	m 
	h 
	s
}  

INITIAL {
	rates(v,cai)
        m = minf
        h = hinf
	s = s_inf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	po = m*m*h
 	ica = gcalbar *po*h2(cai) * (v - eca)

}


FUNCTION ghk(v(mV), ci(mM), co(mM)) (.001 coul/cm3) {
	LOCAL z, eci, eco
	z = (1e-3)*2*FARADAY*v/(R*(celsius+273.15))
	eco = co*efun(z)
	eci = ci*efun(-z)
	:high cao charge moves inward
	:negative potential charge moves inward
	ghk = (.001)*2*FARADAY*(eci - eco)
}

FUNCTION efun(z) {
	if (fabs(z) < 1e-4) {
		efun = 1 - z/2
	}else{
		efun = z/(exp(z) - 1)
	}
}

DERIVATIVE states {
	rates(v,cai)
	m' = (minf -m)/tm0
	h'=  (hinf - h)/th0
	s' = (s_inf-s)/taumin
}



PROCEDURE rates(v (mV), cai(mM)) { 
        LOCAL a, b, alpha2
        
	a = alpm(v)
	minf = 1/(1+a)
        
        b = alph(v)
	hinf = 1/(1+b)
	alpha2 = (ki/cai)^2
	s_inf = alpha2 / (alpha2 + 1)
}




FUNCTION alpm(v(mV)) {
UNITSOFF
  alpm = exp(1.e-3*zetam*(v-vhalfm)*9.648e4/(8.315*(273.16+celsius))) 
UNITSON
}

FUNCTION alph(v(mV)) {
UNITSOFF
  alph = exp(1.e-3*zetah*(v-vhalfh)*9.648e4/(8.315*(273.16+celsius))) 
UNITSON
}


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