GC model (Beining et al 2017)

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Accession:231818
A companion modeldb entry (NEURON only) to modeldb accession number 231862.
Reference:
1 . Beining M, Mongiat LA, Schwarzacher SW, Cuntz H, Jedlicka P (2017) T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells eLife
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Dentate gyrus;
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I A; I Calcium; I h; I K; I K,Ca; I K,leak; I Na,t; I M; Kir2 leak;
Gap Junctions:
Receptor(s):
Gene(s): Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Cav3.2 CACNA1H; HCN1; Nav1.2 SCN2A; Nav1.6 SCN8A; Kir2.1 KCNJ2; Kv1.1 KCNA1; Kv1.4 KCNA4; Kv2.1 KCNB1; Kv3.3 KCNC3; Kv3.4 KCNC4; Kv4.2 KCND2; KCa1.1 KCNMA1; KCa2.2 KCNN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Methods; Neurogenesis; Conductance distributions;
Implementer(s): Beining, Marcel [beining at fias.uni-frankfurt.de];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; Kir2 leak;

// ***** Insert mechanisms *****
for CELLINDEX = 0,cellList.count-1 {
	hasGCL = 0
	forsec cellList.o(CELLINDEX).allreg {
	insert pas
	e_pas = -70
	g_pas = 2.5e-05
	Ra = 210
	cm = 1
	insert k_ion
	ek = -85
	insert na_ion
	ena = 45
	insert ca_ion
	cao0_ca_ion = 2
	cai0_ca_ion = 7e-05
	if (issection(".*GCL.*")) {
		hasGCL = 1
		}
	}
	
	if (hasGCL) {
		forsec cellList.o(CELLINDEX).regGCL {
		insert ichan3
		gnabar_ichan3 = 0.018
		gkfbar_ichan3 = 0.004
		gksbar_ichan3 = 0.003
		gkabar_ichan3 = 0
		insert Caold
		gtcabar_Caold = 0.0003
		gncabar_Caold = 0.003
		glcabar_Caold = 0.015
		insert CadepK
		gbkbar_CadepK = 0.0003
		gskbar_CadepK = 0.0002
		insert pas
		e_pas = -70
		g_pas = 2.5e-05
		Ra = 210
		cm = 1
	}
	}
	forsec cellList.o(CELLINDEX).regadendIML {
	insert pas
	e_pas = -70
	g_pas = 6e-05
	Ra = 210
	cm = 2.4
	insert ichan3
	gnabar_ichan3 = 0.013
	gkfbar_ichan3 = 0.004
	gksbar_ichan3 = 0.003
	gkabar_ichan3 = 0
	insert Caold
	gtcabar_Caold = 0.001
	gncabar_Caold = 0.001
	glcabar_Caold = 0.015
	insert CadepK
	gbkbar_CadepK = 0.0005
	gskbar_CadepK = 0.0001
	}

	forsec cellList.o(CELLINDEX).regadendMML {
	insert pas
	e_pas = -70
	g_pas = 8e-05
	Ra = 210
	cm = 3.2
	insert ichan3
	gnabar_ichan3 = 0.008
	gkfbar_ichan3 = 0.001
	gksbar_ichan3 = 0.003
	gkabar_ichan3 = 0
	insert Caold
	gtcabar_Caold = 0.002
	gncabar_Caold = 0.001
	glcabar_Caold = 0.001
	insert CadepK
	gbkbar_CadepK = 0.0012
	gskbar_CadepK = 0
	}

	forsec cellList.o(CELLINDEX).regadendOML {
	insert pas
	e_pas = -70
	g_pas = 8e-05
	Ra = 210
	cm = 3.2
	insert ichan3
	gnabar_ichan3 = 0
	gkfbar_ichan3 = 0.001
	gksbar_ichan3 = 0.004
	gkabar_ichan3 = 0
	insert Caold
	gtcabar_Caold = 0.002
	gncabar_Caold = 0.001
	glcabar_Caold = 0
	insert CadepK
	gbkbar_CadepK = 0.0012
	gskbar_CadepK = 0
	}

	forsec cellList.o(CELLINDEX).regaxon {
	insert ichan3
	gnabar_ichan3 = 0.21
	gkfbar_ichan3 = 0.028
	gksbar_ichan3 = 0
	gkabar_ichan3 = 0.004
	insert pas
	e_pas = -70
	g_pas = 2.5e-05
	Ra = 210
	cm = 1
	}

	forsec cellList.o(CELLINDEX).regaxonh {
	insert ichan3
	gnabar_ichan3 = 0.21
	gkfbar_ichan3 = 0.028
	gksbar_ichan3 = 0
	gkabar_ichan3 = 0.004
	insert pas
	e_pas = -70
	g_pas = 2.5e-05
	Ra = 210
	cm = 1
	}

	forsec cellList.o(CELLINDEX).regsoma {
	insert ichan3
	gnabar_ichan3 = 0.12
	gkfbar_ichan3 = 0.016
	gksbar_ichan3 = 0.003
	gkabar_ichan3 = 0.012
	insert Caold
	gtcabar_Caold = 0.00015
	gncabar_Caold = 0.002
	glcabar_Caold = 0.01
	insert CadepK
	gbkbar_CadepK = 0.0003
	gskbar_CadepK = 0.0005
	insert pas
	e_pas = -70
	g_pas = 2.5e-05
	Ra = 210
	cm = 1
	}
	// ***** Define nseg for all cells *****
	geom_nseg()
	}

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