GC model (Beining et al 2017)

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Accession:231818
A companion modeldb entry (NEURON only) to modeldb accession number 231862.
Reference:
1 . Beining M, Mongiat LA, Schwarzacher SW, Cuntz H, Jedlicka P (2017) T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells eLife
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Dentate gyrus;
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I A; I Calcium; I h; I K; I K,Ca; I K,leak; I Na,t; I M; Kir2 leak;
Gap Junctions:
Receptor(s):
Gene(s): Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Cav3.2 CACNA1H; HCN1; Nav1.2 SCN2A; Nav1.6 SCN8A; Kir2.1 KCNJ2; Kv1.1 KCNA1; Kv1.4 KCNA4; Kv2.1 KCNB1; Kv3.3 KCNC3; Kv3.4 KCNC4; Kv4.2 KCND2; KCa1.1 KCNMA1; KCa2.2 KCNN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Methods; Neurogenesis; Conductance distributions;
Implementer(s): Beining, Marcel [beining at fias.uni-frankfurt.de];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; Kir2 leak;

// ***** Insert mechanisms *****
for CELLINDEX = 0,cellList.count-1 {
	hasGCL = 0
	forsec cellList.o(CELLINDEX).allreg {
	insert Cabuffer
	brat_Cabuffer = 50
	tau_Cabuffer = 240
	depth_Cabuffer = 0.05
	insert k_ion
	ek = -93
	insert na_ion
	ena = 87.76
	insert ca_ion
	cao0_ca_ion = 2
	cai0_ca_ion = 4.8e-05
	if (issection(".*GCL.*")) {
		hasGCL = 1
		}
	}
	
	if (hasGCL) {
		forsec cellList.o(CELLINDEX).regGCL {
		insert pas
		cm = 0.9
		Ra = 200
		g_pas = 1.38462e-05
		e_pas = -80
		insert Kir21
		gkbar_Kir21 = 0.000141561
		mg_i_Kir21 = 4
		spm_i_Kir21 = 1
		gsub_Kir21 = 0.25
		fac_Kir21 = 0.005
		vshiftbs_Kir21 = 0
		vshiftbb_Kir21 = 0
		b_Kir21 = 0.105
		shiftmg_Kir21 = 0.5
		cas_Kir21 = 0.142857
		As_Kir21 = 0.2
		insert Kv42
		gkbar_Kv42 = 0.002175
		a0_Kv42 = 0.416
		za_Kv42 = 1.1
		b0_Kv42 = 0.0486
		zb_Kv42 = -1.556
		kco0_Kv42 = 0.347
		zco_Kv42 = 0
		koc0_Kv42 = 1.67
		zoc_Kv42 = 0
		kci_Kv42 = 0.04873
		kic_Kv42 = 0.000537
		koi_Kv42 = 0.0669
		kio_Kv42 = 0.04246
		vshift_Kv42 = -20
		insert Cav22
		gbar_Cav22 = 5e-05
		insert Cav12
		VDI_Cav12 = 1
		gbar_Cav12 = 1e-05
		kf_Cav12 = 0.0005
		insert Cav13
		VDI_Cav13 = 0.85
		gbar_Cav13 = 4e-06
		insert Cav32
		gbar_Cav32 = 2.2e-05
		insert SK2
		gkbar_SK2 = 1.66667e-06
		diff_SK2 = 3
		Q10_SK2 = 5
		fac_SK2 = 2.5
		diro2_SK2 = 0.1
		invc3_SK2 = 0.09
		invc1_SK2 = 0.32
		invc2_SK2 = 0.32
		dirc4_SK2 = 320
		insert Cabuffer
		brat_Cabuffer = 50
		tau_Cabuffer = 240
		depth_Cabuffer = 0.05
		}
	}
	forsec cellList.o(CELLINDEX).regadendIML {
	insert pas
	cm = 1.305
	Ra = 200
	g_pas = 2.00769e-05
	e_pas = -80
	insert Kir21
	gkbar_Kir21 = 0.000141561
	mg_i_Kir21 = 4
	spm_i_Kir21 = 1
	gsub_Kir21 = 0.25
	fac_Kir21 = 0.005
	vshiftbs_Kir21 = 0
	vshiftbb_Kir21 = 0
	b_Kir21 = 0.105
	shiftmg_Kir21 = 0.5
	cas_Kir21 = 0.142857
	As_Kir21 = 0.2
	insert HCN
	cAMP_HCN = 0
	e_HCN = -41.9
	gbar_HCN = 4e-06
	vhalfl_HCN = -100
	kl_HCN = 8
	vhalft_HCN = 30.4
	at_HCN = 0.00052
	bt_HCN = 0.2151
	insert Kv42
	gkbar_Kv42 = 0.00435
	a0_Kv42 = 0.416
	za_Kv42 = 1.1
	b0_Kv42 = 0.0486
	zb_Kv42 = -1.556
	kco0_Kv42 = 0.347
	zco_Kv42 = 0
	koc0_Kv42 = 1.67
	zoc_Kv42 = 0
	kci_Kv42 = 0.04873
	kic_Kv42 = 0.000537
	koi_Kv42 = 0.0669
	kio_Kv42 = 0.04246
	vshift_Kv42 = -20
	insert Cav22
	gbar_Cav22 = 5e-05
	hTau_Cav22 = 80
	insert Cav12
	VDI_Cav12 = 1
	gbar_Cav12 = 4e-05
	kf_Cav12 = 0.0005
	insert Cav13
	VDI_Cav13 = 0.85
	gbar_Cav13 = 8e-06
	kf_Cav13 = 0.0005
	insert Cav32
	gbar_Cav32 = 2.2e-05
	insert SK2
	gkbar_SK2 = 4.375e-06
	diff_SK2 = 3
	Q10_SK2 = 5
	fac_SK2 = 2.5
	diro2_SK2 = 0.1
	invc3_SK2 = 0.09
	invc1_SK2 = 0.32
	invc2_SK2 = 0.32
	dirc4_SK2 = 320
	insert Cabuffer
	brat_Cabuffer = 50
	tau_Cabuffer = 240
	depth_Cabuffer = 0.05
	}

	forsec cellList.o(CELLINDEX).regadendMML {
	insert pas
	cm = 1.71
	Ra = 200
	g_pas = 2.63076e-05
	e_pas = -80
	insert Kir21
	gkbar_Kir21 = 0.000141561
	mg_i_Kir21 = 4
	spm_i_Kir21 = 1
	gsub_Kir21 = 0.25
	fac_Kir21 = 0.005
	vshiftbs_Kir21 = 0
	vshiftbb_Kir21 = 0
	b_Kir21 = 0.105
	shiftmg_Kir21 = 0.5
	cas_Kir21 = 0.142857
	As_Kir21 = 0.2
	insert HCN
	cAMP_HCN = 0
	e_HCN = -41.9
	gbar_HCN = 4e-06
	vhalfl_HCN = -100
	kl_HCN = 8
	vhalft_HCN = 30.4
	at_HCN = 0.00052
	bt_HCN = 0.2151
	insert Kv42
	gkbar_Kv42 = 0.00435
	a0_Kv42 = 0.416
	za_Kv42 = 1.1
	b0_Kv42 = 0.0486
	zb_Kv42 = -1.556
	kco0_Kv42 = 0.347
	zco_Kv42 = 0
	koc0_Kv42 = 1.67
	zoc_Kv42 = 0
	kci_Kv42 = 0.04873
	kic_Kv42 = 0.000537
	koi_Kv42 = 0.0669
	kio_Kv42 = 0.04246
	vshift_Kv42 = -20
	insert Cav22
	gbar_Cav22 = 5e-05
	hTau_Cav22 = 80
	insert Cav12
	VDI_Cav12 = 1
	gbar_Cav12 = 4e-05
	kf_Cav12 = 0.0005
	insert Cav13
	VDI_Cav13 = 0.85
	gbar_Cav13 = 8e-06
	kf_Cav13 = 0.0005
	insert Cav32
	gbar_Cav32 = 2.2e-05
	insert SK2
	gkbar_SK2 = 4.375e-06
	diff_SK2 = 3
	Q10_SK2 = 5
	fac_SK2 = 2.5
	diro2_SK2 = 0.1
	invc3_SK2 = 0.09
	invc1_SK2 = 0.32
	invc2_SK2 = 0.32
	dirc4_SK2 = 320
	insert Cabuffer
	brat_Cabuffer = 50
	tau_Cabuffer = 240
	depth_Cabuffer = 0.05
	}

	forsec cellList.o(CELLINDEX).regadendOML {
	insert pas
	cm = 1.71
	Ra = 200
	g_pas = 2.63076e-05
	e_pas = -80
	insert Kir21
	gkbar_Kir21 = 0.000141561
	mg_i_Kir21 = 4
	spm_i_Kir21 = 1
	gsub_Kir21 = 0.25
	fac_Kir21 = 0.005
	vshiftbs_Kir21 = 0
	vshiftbb_Kir21 = 0
	b_Kir21 = 0.105
	shiftmg_Kir21 = 0.5
	cas_Kir21 = 0.142857
	As_Kir21 = 0.2
	insert HCN
	cAMP_HCN = 0
	e_HCN = -41.9
	gbar_HCN = 4e-06
	vhalfl_HCN = -100
	kl_HCN = 8
	vhalft_HCN = 30.4
	at_HCN = 0.00052
	bt_HCN = 0.2151
	insert Kv42
	gkbar_Kv42 = 0.00435
	a0_Kv42 = 0.416
	za_Kv42 = 1.1
	b0_Kv42 = 0.0486
	zb_Kv42 = -1.556
	kco0_Kv42 = 0.347
	zco_Kv42 = 0
	koc0_Kv42 = 1.67
	zoc_Kv42 = 0
	kci_Kv42 = 0.04873
	kic_Kv42 = 0.000537
	koi_Kv42 = 0.0669
	kio_Kv42 = 0.04246
	vshift_Kv42 = -20
	insert Cav22
	gbar_Cav22 = 5e-05
	hTau_Cav22 = 80
	insert Cav12
	VDI_Cav12 = 1
	gbar_Cav12 = 4e-05
	kf_Cav12 = 0.0005
	insert Cav13
	VDI_Cav13 = 0.85
	gbar_Cav13 = 8e-06
	kf_Cav13 = 0.0005
	insert Cav32
	gbar_Cav32 = 2.2e-05
	insert SK2
	gkbar_SK2 = 4.375e-06
	diff_SK2 = 3
	Q10_SK2 = 5
	fac_SK2 = 2.5
	diro2_SK2 = 0.1
	invc3_SK2 = 0.09
	invc1_SK2 = 0.32
	invc2_SK2 = 0.32
	dirc4_SK2 = 320
	insert Cabuffer
	brat_Cabuffer = 50
	tau_Cabuffer = 240
	depth_Cabuffer = 0.05
	}

	forsec cellList.o(CELLINDEX).regaxon {
	insert pas
	cm = 0.9
	Ra = 100
	g_pas = 6.59341e-06
	e_pas = -80
	insert Kir21
	gkbar_Kir21 = 6.741e-05
	mg_i_Kir21 = 4
	spm_i_Kir21 = 1
	gsub_Kir21 = 0.25
	fac_Kir21 = 0.005
	vshiftbs_Kir21 = 0
	vshiftbb_Kir21 = 0
	b_Kir21 = 0.105
	shiftmg_Kir21 = 0.5
	cas_Kir21 = 0.142857
	As_Kir21 = 0.2
	insert na8st
	vShift_na8st = 22
	vShift_inact_na8st = 0
	a1_0_na8st = 62.6477
	a1_1_na8st = 0.0116055
	b1_0_na8st = 0.00193691
	b1_1_na8st = 0.137719
	a2_0_na8st = 34.7828
	a2_1_na8st = 0.0299559
	b2_0_na8st = 0.0957515
	b2_1_na8st = 0.0928114
	a3_0_na8st = 76.6983
	a3_1_na8st = 0.0537432
	b3_0_na8st = 1.24879
	b3_1_na8st = 0.0311504
	bh_0_na8st = 2.9807
	bh_1_na8st = 0.4679
	bh_2_na8st = 0.0596
	ah_0_na8st = 0.3962
	ah_1_na8st = 2982.1
	ah_2_na8st = 0.0635
	gbar_na8st = 0.088128
	insert Kv11
	gkbar_Kv11 = 0.00025
	vshift_Kv11 = 0
	insert Kv14
	gkbar_Kv14 = 0.001
	vshift_Kv14 = 0
	insert Kv34
	gkbar_Kv34 = 0.00765625
	scale_a_Kv34 = 4
	ksl_Kv34 = 0.5
	insert Kv723
	gkbar_Kv723 = 0.00134
	Dtaumult1_Kv723 = 6
	Dtaumult2_Kv723 = 6
	tau0mult_Kv723 = 0.2
	insert Cabuffer
	brat_Cabuffer = 10
	tau_Cabuffer = 43
	insert Cav22
	gbar_Cav22 = 5e-05
	hTau_Cav22 = 80
	insert Cav13
	VDI_Cav13 = 0.85
	gbar_Cav13 = 4e-06
	kf_Cav13 = 0.0005
	insert Cav32
	gbar_Cav32 = 8e-06
	insert BK
	gabkbar_BK = 0.0156
	gakbar_BK = 0.0624
	diff_BK = 100000
	base_BK = 4
	insert SK2
	gkbar_SK2 = 1.25e-05
	diff_SK2 = 3
	Q10_SK2 = 5
	fac_SK2 = 2.5
	diro2_SK2 = 0.1
	invc3_SK2 = 0.09
	invc1_SK2 = 0.32
	invc2_SK2 = 0.32
	dirc4_SK2 = 320
	}

	forsec cellList.o(CELLINDEX).regaxonh {
	insert pas
	cm = 0.9
	Ra = 200
	g_pas = 6.59341e-06
	e_pas = -80
	insert Kir21
	gkbar_Kir21 = 6.741e-05
	mg_i_Kir21 = 4
	spm_i_Kir21 = 1
	gsub_Kir21 = 0.25
	fac_Kir21 = 0.005
	vshiftbs_Kir21 = 0
	vshiftbb_Kir21 = 0
	b_Kir21 = 0.105
	shiftmg_Kir21 = 0.5
	cas_Kir21 = 0.142857
	As_Kir21 = 0.2
	insert na8st
	vShift_na8st = 22
	vShift_inact_na8st = 0
	a1_0_na8st = 62.6477
	a1_1_na8st = 0.0116055
	b1_0_na8st = 0.00193691
	b1_1_na8st = 0.137719
	a2_0_na8st = 34.7828
	a2_1_na8st = 0.0299559
	b2_0_na8st = 0.0957515
	b2_1_na8st = 0.0928114
	a3_0_na8st = 76.6983
	a3_1_na8st = 0.0537432
	b3_0_na8st = 1.24879
	b3_1_na8st = 0.0311504
	bh_0_na8st = 2.9807
	bh_1_na8st = 0.4679
	bh_2_na8st = 0.0596
	ah_0_na8st = 0.3962
	ah_1_na8st = 2982.1
	ah_2_na8st = 0.0635
	gbar_na8st = 0.5184
	insert Kv11
	gkbar_Kv11 = 0.00025
	vshift_Kv11 = 0
	insert Kv14
	gkbar_Kv14 = 0.001
	vshift_Kv14 = 0
	insert Kv34
	gkbar_Kv34 = 0.0307813
	scale_a_Kv34 = 4
	ksl_Kv34 = 0.5
	insert Kv723
	gkbar_Kv723 = 0.0067
	Dtaumult1_Kv723 = 6
	Dtaumult2_Kv723 = 6
	tau0mult_Kv723 = 0.2
	insert Cav22
	gbar_Cav22 = 5e-05
	hTau_Cav22 = 80
	insert Cav12
	VDI_Cav12 = 1
	gbar_Cav12 = 1e-05
	kf_Cav12 = 0.0005
	insert Cav13
	VDI_Cav13 = 0.85
	gbar_Cav13 = 8e-06
	kf_Cav13 = 0.0005
	insert Cav32
	gbar_Cav32 = 8e-06
	insert BK
	gabkbar_BK = 0.0156
	gakbar_BK = 0.0624
	diff_BK = 100000
	base_BK = 4
	insert SK2
	gkbar_SK2 = 8.33333e-05
	diff_SK2 = 3
	Q10_SK2 = 5
	fac_SK2 = 2.5
	diro2_SK2 = 0.1
	invc3_SK2 = 0.09
	invc1_SK2 = 0.32
	invc2_SK2 = 0.32
	dirc4_SK2 = 320
	insert Cabuffer
	brat_Cabuffer = 50
	tau_Cabuffer = 240
	depth_Cabuffer = 0.05
	}

	forsec cellList.o(CELLINDEX).regsoma {
	insert pas
	cm = 0.9
	Ra = 200
	g_pas = 1.38462e-05
	e_pas = -80
	insert Kir21
	gkbar_Kir21 = 0.000141561
	mg_i_Kir21 = 4
	spm_i_Kir21 = 1
	gsub_Kir21 = 0.25
	fac_Kir21 = 0.005
	vshiftbs_Kir21 = 0
	vshiftbb_Kir21 = 0
	b_Kir21 = 0.105
	shiftmg_Kir21 = 0.5
	cas_Kir21 = 0.142857
	As_Kir21 = 0.2
	insert na8st
	vShift_na8st = 22
	vShift_inact_na8st = 0
	a1_0_na8st = 45.8498
	a1_1_na8st = 0.0239354
	b1_0_na8st = 0.0144095
	b1_1_na8st = 0.0884761
	a2_0_na8st = 19.8084
	a2_1_na8st = 0.0221771
	b2_0_na8st = 0.565017
	b2_1_na8st = 0.061084
	a3_0_na8st = 71.8119
	a3_1_na8st = 0.0659379
	b3_0_na8st = 0.753118
	b3_1_na8st = 0.0364798
	bh_0_na8st = 2.9713
	bh_1_na8st = 0.6443
	bh_2_na8st = 0.0594
	ah_0_na8st = 1.586
	ah_1_na8st = 2306.7
	ah_2_na8st = 0.0493
	gbar_na8st = 0.088128
	insert Kv21
	gkbar_Kv21 = 0.00709091
	insert Cabuffer
	brat_Cabuffer = 200
	tau_Cabuffer = 240
	insert Cav22
	gbar_Cav22 = 0.0003
	hTau_Cav22 = 80
	insert Cav12
	VDI_Cav12 = 1
	gbar_Cav12 = 2e-05
	kf_Cav12 = 0.0005
	insert Cav13
	VDI_Cav13 = 0.85
	gbar_Cav13 = 1.6e-05
	kf_Cav13 = 0.0005
	insert Cav32
	gbar_Cav32 = 2.2e-05
	insert BK
	gabkbar_BK = 0.0039
	gakbar_BK = 0.0156
	diff_BK = 1.5
	base_BK = 4
	insert SK2
	gkbar_SK2 = 8.33333e-07
	diff_SK2 = 3
	Q10_SK2 = 5
	fac_SK2 = 2.5
	diro2_SK2 = 0.1
	invc3_SK2 = 0.09
	invc1_SK2 = 0.32
	invc2_SK2 = 0.32
	dirc4_SK2 = 320
	}

	// ***** Now adjust number of segments *****
	geom_nseg()
	}

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