Mesoscopic dynamics from AdEx recurrent networks (Zerlaut et al., JCNS 2017)

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We present a mean-field model of networks of Adaptive Exponential (AdEx) integrate-and-fire neurons, with conductance-based synaptic interactions. We study a network of regular-spiking (RS) excitatory neurons and fast-spiking (FS) inhibitory neurons. We use a Master Equation formalism, together with a semi-analytic approach to the transfer function of AdEx neurons to describe the average dynamics of the coupled populations. We compare the predictions of this mean-field model to simulated networks of RS-FS cells, first at the level of the spontaneous activity of the network, which is well predicted by the analytical description. Second, we investigate the response of the network to time-varying external input, and show that the mean-field model predicts the response time course of the population. Finally, to model VSDi signals, we consider a one-dimensional ring model made of interconnected RS-FS mean-field units.
1 . Zerlaut Y, Chemla S, Chavane F, Destexhe A (2018) Modeling mesoscopic cortical dynamics using a mean-field model of conductance-based networks of adaptive exponential integrate-and-fire neurons. J Comput Neurosci 44:45-61 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Abstract integrate-and-fire adaptive exponential (AdEx) neuron;
Gap Junctions:
Simulation Environment: Brian 2; Python;
Model Concept(s): Vision;
import matplotlib.pylab as plt

def add_subplot_axes(ax,rect,facecolor='w'):
    fig = plt.gcf()
    box = ax.get_position()
    width = box.width
    height = box.height
    inax_position  = ax.transAxes.transform(rect[0:2])
    transFigure = fig.transFigure.inverted()
    infig_position = transFigure.transform(inax_position)    
    x = infig_position[0]
    y = infig_position[1]
    width *= rect[2]
    height *= rect[3]  # <= Typo was here
    subax = fig.add_axes([x,y,width,height],facecolor=facecolor)
    x_labelsize = subax.get_xticklabels()[0].get_size()
    y_labelsize = subax.get_yticklabels()[0].get_size()
    x_labelsize *= rect[2]**0.5
    y_labelsize *= rect[3]**0.5
    return subax

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