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Robust modulation of integrate-and-fire models (Van Pottelbergh et al 2018)
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"By controlling the state of neuronal populations, neuromodulators ultimately affect behavior. A key neuromodulation mechanism is the alteration of neuronal excitability via the modulation of ion channel expression. This type of neuromodulation is normally studied with conductance-based models, but those models are computationally challenging for large-scale network simulations needed in population studies. This article studies the modulation properties of the multiquadratic integrate-and-fire model, a generalization of the classical quadratic integrate-and-fire model. The model is shown to combine the computational economy of integrate-and-fire modeling and the physiological interpretability of conductance-based modeling. It is therefore a good candidate for affordable computational studies of neuromodulation in large networks."
Van Pottelbergh T, Drion G, Sepulchre R (2018) Robust Modulation of Integrate-and-Fire Models.
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Neuron or other electrically excitable cell;
Abstract Izhikevich neuron;
Abstract integrate-and-fire adaptive exponential (AdEx) neuron;
Abstract integrate-and-fire neuron;
Action Potential Initiation;
Van Pottelbergh, Tomas [tmjv2 at cam.ac.uk];
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