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Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
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Model Information
Model File
Citations
Accession:
235320
Computational modeling showed that the size of the Axon Initial Segment (AIS), but not its position within the somatodendritic domain, is the major causal determinant of the tonic firing rate in the intact model, by virtue of the higher intrinsic frequency of the isolated AIS. Further mechanistic analysis of the relationship between neuronal morphology and firing rate showed that dopaminergic neurons function as a coupled oscillator whose frequency of discharge results from a compromise between AIS and somatodendritic oscillators.
Reference:
1 .
Meza RC, López-Jury L, Canavier CC, Henny P (2018) Role of the Axon Initial Segment in the Control of Spontaneous Frequency of Nigral Dopaminergic Neurons In Vivo.
J Neurosci
38
:733-744
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Basal ganglia;
Mouse;
Cell Type(s):
Substantia nigra pars compacta DA cell;
Channel(s):
Na/K pump;
I K,Ca;
I K;
I L high threshold;
I T low threshold;
I A;
I N;
I Na,t;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Temporal Pattern Generation;
Oscillations;
Pacemaking mechanism;
Implementer(s):
Lopez-Jury, Luciana [lucianalopezjury at gmail.com];
Canavier, CC;
Search NeuronDB
for information about:
Substantia nigra pars compacta DA cell
;
I Na,t
;
I L high threshold
;
I N
;
I T low threshold
;
I A
;
I K
;
I K,Ca
;
Na/K pump
;
Download the displayed file
/
DAfreq_AIS
README.txt
cabal.mod
*
Other models using cabal.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)
VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)
nabalan.mod
*
Other models using nabalan.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)
newcachan.mod
*
Other models using newcachan.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)
newkca.mod
*
Other models using newkca.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
newleak.mod
pump.mod
*
Other models using pump.mod:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
slowhh3.mod
dopaminergic.hoc
final.hoc
fixnseg.hoc
*
Other models using fixnseg.hoc:
Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)
mosinit.hoc
sesion.ses
load_file("nrngui.hoc") xopen("final.hoc")
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