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Fast Spiking Basket cells (Tzilivaki et al 2019)

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Accession:237595
"Interneurons are critical for the proper functioning of neural circuits. While often morphologically complex, dendritic integration and its role in neuronal output have been ignored for decades, treating interneurons as linear point neurons. Exciting new findings suggest that interneuron dendrites support complex, nonlinear computations: sublinear integration of EPSPs in the cerebellum, coupled to supralinear calcium accumulations and supralinear voltage integration in the hippocampus. These findings challenge the point neuron dogma and call for a new theory of interneuron arithmetic. Using detailed, biophysically constrained models, we predict that dendrites of FS basket cells in both hippocampus and mPFC come in two flavors: supralinear, supporting local sodium spikes within large-volume branches and sublinear, in small-volume branches. Synaptic activation of varying sets of these dendrites leads to somatic firing variability that cannot be explained by the point neuron reduction. Instead, a 2-stage Artificial Neural Network (ANN), with both sub- and supralinear hidden nodes, captures most of the variance. We propose that FS basket cells have substantially expanded computational capabilities sub-served by their non-linear dendrites and act as a 2-layer ANN."
Reference:
1 . Tzilivaki A, Kastellakis G, Poirazi P (2019) Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators Nature Communications 10(1):3664 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus; Prefrontal cortex (PFC);
Cell Type(s): Hippocampus CA3 interneuron basket GABA cell; Neocortex layer 5 interneuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB; Python;
Model Concept(s): Active Dendrites; Detailed Neuronal Models;
Implementer(s): Tzilivaki, Alexandra [alexandra.tzilivaki at charite.de]; Kastellakis, George [gkastel at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 interneuron basket GABA cell;
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TzilivakiEtal_FSBCs_model
Multicompartmental_Biophysical_models
mechanism
x86_64
.libs
ampa.mod *
ampain.mod *
cadyn.mod *
cadynin.mod *
cal.mod *
calc.mod *
calcb.mod *
can.mod *
cancr.mod *
canin.mod *
car.mod *
cat.mod *
catcb.mod *
cpampain.mod *
gabaa.mod *
gabaain.mod *
gabab.mod *
h.mod *
hcb.mod *
hin.mod *
ican.mod *
iccb.mod *
iccr.mod *
icin.mod *
iks.mod *
ikscb.mod *
ikscr.mod *
iksin.mod *
kadist.mod *
kadistcr.mod *
kadistin.mod *
kaprox.mod *
kaproxcb.mod *
kaproxin.mod *
kca.mod *
kcain.mod *
kct.mod *
kctin.mod *
kdr.mod *
kdrcb.mod *
kdrcr.mod *
kdrin.mod *
naf.mod *
nafcb.mod *
nafcr.mod *
nafin.mod *
nafx.mod *
nap.mod *
netstim.mod *
NMDA.mod *
NMDAIN.mod *
sinclamp.mod *
vecstim.mod *
ampa.c
ampa.lo
ampain.c
ampain.lo
cadyn.c
cadyn.lo
cadynin.c
cadynin.lo
cal.c
cal.lo
calc.c
calc.lo
calcb.c
calcb.lo
can.c
can.lo
cancr.c
cancr.lo
canin.c
canin.lo
car.c
car.lo
cat.c
cat.lo
catcb.c
catcb.lo
cpampain.c
cpampain.lo
gabaa.c
gabaa.lo
gabaain.c
gabaain.lo
gabab.c
gabab.lo
h.c
h.lo
hcb.c
hcb.lo
hin.c
hin.lo
ican.c
ican.lo
iccb.c
iccb.lo
iccr.c
iccr.lo
icin.c
icin.lo
iks.c
iks.lo
ikscb.c
ikscb.lo
ikscr.c
ikscr.lo
iksin.c
iksin.lo
kadist.c
kadist.lo
kadistcr.c
kadistcr.lo
kadistin.c
kadistin.lo
kaprox.c
kaprox.lo
kaproxcb.c
kaproxcb.lo
kaproxin.c
kaproxin.lo
kca.c
kca.lo
kcain.c
kcain.lo
kct.c
kct.lo
kctin.c
kctin.lo
kdr.c
kdr.lo
kdrcb.c
kdrcb.lo
kdrcr.c
kdrcr.lo
kdrin.c
kdrin.lo
libnrnmech.la *
mod_func.c
mod_func.lo *
naf.c
naf.lo
nafcb.c
nafcb.lo
nafcr.c
nafcr.lo
nafin.c
nafin.lo
nafx.c
nafx.lo
nap.c
nap.lo
netstim.c
netstim.lo
NMDA.c
NMDA.lo
NMDAIN.c
NMDAIN.lo
sinclamp.c
sinclamp.lo
special
vecstim.c
vecstim.lo
                            
#include <stdio.h>
#include "hocdec.h"
extern int nrnmpi_myid;
extern int nrn_nobanner_;

extern void _ampain_reg(void);
extern void _ampa_reg(void);
extern void _cadynin_reg(void);
extern void _cadyn_reg(void);
extern void _calcb_reg(void);
extern void _calc_reg(void);
extern void _cal_reg(void);
extern void _cancr_reg(void);
extern void _canin_reg(void);
extern void _can_reg(void);
extern void _car_reg(void);
extern void _catcb_reg(void);
extern void _cat_reg(void);
extern void _cpampain_reg(void);
extern void _gabaain_reg(void);
extern void _gabaa_reg(void);
extern void _gabab_reg(void);
extern void _hcb_reg(void);
extern void _hin_reg(void);
extern void _h_reg(void);
extern void _ican_reg(void);
extern void _iccb_reg(void);
extern void _iccr_reg(void);
extern void _icin_reg(void);
extern void _ikscb_reg(void);
extern void _ikscr_reg(void);
extern void _iksin_reg(void);
extern void _iks_reg(void);
extern void _kadistcr_reg(void);
extern void _kadistin_reg(void);
extern void _kadist_reg(void);
extern void _kaproxcb_reg(void);
extern void _kaproxin_reg(void);
extern void _kaprox_reg(void);
extern void _kcain_reg(void);
extern void _kca_reg(void);
extern void _kctin_reg(void);
extern void _kct_reg(void);
extern void _kdrcb_reg(void);
extern void _kdrcr_reg(void);
extern void _kdrin_reg(void);
extern void _kdr_reg(void);
extern void _nafcb_reg(void);
extern void _nafcr_reg(void);
extern void _nafin_reg(void);
extern void _naf_reg(void);
extern void _nafx_reg(void);
extern void _nap_reg(void);
extern void _netstim_reg(void);
extern void _NMDAIN_reg(void);
extern void _NMDA_reg(void);
extern void _sinclamp_reg(void);
extern void _vecstim_reg(void);

void modl_reg(){
  if (!nrn_nobanner_) if (nrnmpi_myid < 1) {
    fprintf(stderr, "Additional mechanisms from files\n");

    fprintf(stderr," ampain.mod");
    fprintf(stderr," ampa.mod");
    fprintf(stderr," cadynin.mod");
    fprintf(stderr," cadyn.mod");
    fprintf(stderr," calcb.mod");
    fprintf(stderr," calc.mod");
    fprintf(stderr," cal.mod");
    fprintf(stderr," cancr.mod");
    fprintf(stderr," canin.mod");
    fprintf(stderr," can.mod");
    fprintf(stderr," car.mod");
    fprintf(stderr," catcb.mod");
    fprintf(stderr," cat.mod");
    fprintf(stderr," cpampain.mod");
    fprintf(stderr," gabaain.mod");
    fprintf(stderr," gabaa.mod");
    fprintf(stderr," gabab.mod");
    fprintf(stderr," hcb.mod");
    fprintf(stderr," hin.mod");
    fprintf(stderr," h.mod");
    fprintf(stderr," ican.mod");
    fprintf(stderr," iccb.mod");
    fprintf(stderr," iccr.mod");
    fprintf(stderr," icin.mod");
    fprintf(stderr," ikscb.mod");
    fprintf(stderr," ikscr.mod");
    fprintf(stderr," iksin.mod");
    fprintf(stderr," iks.mod");
    fprintf(stderr," kadistcr.mod");
    fprintf(stderr," kadistin.mod");
    fprintf(stderr," kadist.mod");
    fprintf(stderr," kaproxcb.mod");
    fprintf(stderr," kaproxin.mod");
    fprintf(stderr," kaprox.mod");
    fprintf(stderr," kcain.mod");
    fprintf(stderr," kca.mod");
    fprintf(stderr," kctin.mod");
    fprintf(stderr," kct.mod");
    fprintf(stderr," kdrcb.mod");
    fprintf(stderr," kdrcr.mod");
    fprintf(stderr," kdrin.mod");
    fprintf(stderr," kdr.mod");
    fprintf(stderr," nafcb.mod");
    fprintf(stderr," nafcr.mod");
    fprintf(stderr," nafin.mod");
    fprintf(stderr," naf.mod");
    fprintf(stderr," nafx.mod");
    fprintf(stderr," nap.mod");
    fprintf(stderr," netstim.mod");
    fprintf(stderr," NMDAIN.mod");
    fprintf(stderr," NMDA.mod");
    fprintf(stderr," sinclamp.mod");
    fprintf(stderr," vecstim.mod");
    fprintf(stderr, "\n");
  }
  _ampain_reg();
  _ampa_reg();
  _cadynin_reg();
  _cadyn_reg();
  _calcb_reg();
  _calc_reg();
  _cal_reg();
  _cancr_reg();
  _canin_reg();
  _can_reg();
  _car_reg();
  _catcb_reg();
  _cat_reg();
  _cpampain_reg();
  _gabaain_reg();
  _gabaa_reg();
  _gabab_reg();
  _hcb_reg();
  _hin_reg();
  _h_reg();
  _ican_reg();
  _iccb_reg();
  _iccr_reg();
  _icin_reg();
  _ikscb_reg();
  _ikscr_reg();
  _iksin_reg();
  _iks_reg();
  _kadistcr_reg();
  _kadistin_reg();
  _kadist_reg();
  _kaproxcb_reg();
  _kaproxin_reg();
  _kaprox_reg();
  _kcain_reg();
  _kca_reg();
  _kctin_reg();
  _kct_reg();
  _kdrcb_reg();
  _kdrcr_reg();
  _kdrin_reg();
  _kdr_reg();
  _nafcb_reg();
  _nafcr_reg();
  _nafin_reg();
  _naf_reg();
  _nafx_reg();
  _nap_reg();
  _netstim_reg();
  _NMDAIN_reg();
  _NMDA_reg();
  _sinclamp_reg();
  _vecstim_reg();
}

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