Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)

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Accession:237653
We are investigating how dopaminergic modulation of single channels can be combined to make the D1R possitive MSN more excitable. We also connect multiple channels to substrates of a dopamine induced subcellular cascade to highlight that the classical pathway is too slow to explain DA induced kinetics in the subsecond range (Howe and Dombeck, 2016. doi: 10.1038/nature18942)
Reference:
1 . Lindroos R, Dorst MC, Du K, Filipovic M, Keller D, Ketzef M, Kozlov AK, Kumar A, Lindahl M, Nair AG, Pérez-Fernández J, Grillner S, Silberberg G, Hellgren Kotaleski J (2018) Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2. Front Neural Circuits 12:3 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Channel/Receptor; Dendrite; Molecular Network; Synapse; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia; Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum spiny neuron;
Channel(s): I A; I A, slow; I Calcium; I CAN; I K; I K,Ca; I K,leak; I Krp; I Na,t; I Potassium; I R; I T low threshold; Kir;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor; AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Action Potentials; Detailed Neuronal Models; Electrical-chemical; G-protein coupled; Membrane Properties; Neuromodulation; Multiscale; Synaptic noise;
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Du, Kai [kai.du at ki.se]; Keller, Daniel ; Kozlov, Alexander [akozlov at nada.kth.se];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; AMPA; NMDA; Gaba; Dopaminergic Receptor; I Na,t; I T low threshold; I A; I K; I K,leak; I K,Ca; I CAN; I Calcium; I Potassium; I A, slow; I Krp; I R; Kir; Dopamine; Gaba; Glutamate;
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      <species metaid="COPASI17" id="mw6e845d87_603e_4463_874d_866f554303df" name="PDE10*cAMP" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="302.781683628694" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
        <annotation>
          <SimBiology xmlns="http://www.mathworks.com">
            <Unit Numerator="mole" Denominator="liter"/>
          </SimBiology>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI17">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-06-10T13:29:09Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </species>
      <species metaid="COPASI18" id="mw1f3b8982_3b8c_42b6_8b0f_49b037cbda43" name="PDE10c*cAMP" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="0.183961533250013" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
        <annotation>
          <SimBiology xmlns="http://www.mathworks.com">
            <Unit Numerator="mole" Denominator="liter"/>
          </SimBiology>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI18">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-06-10T13:29:11Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </species>
      <species metaid="COPASI19" id="mw46dccec6_6f0f_40f6_a10c_2f34ae7a005a" name="ATP" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="5000000" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="true">
        <annotation>
          <SimBiology xmlns="http://www.mathworks.com">
            <Unit Numerator="mole" Denominator="liter"/>
          </SimBiology>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI19">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T13:14:35Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </species>
      <species id="mw166e3335_56c3_41ef_af0f_b583860991c1" name="AC5GaolfGTP*ATP" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="29.7480375915836" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
        <annotation>
          <SimBiology xmlns="http://www.mathworks.com">
            <Unit Numerator="mole" Denominator="liter"/>
          </SimBiology>
        </annotation>
      </species>
      <species metaid="COPASI20" id="mw7086a13a_619e_4069_b163_d8a05fc55f42" name="AC5*ATP" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="667.46442556075" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
        <annotation>
          <SimBiology xmlns="http://www.mathworks.com">
            <Unit Numerator="mole" Denominator="liter"/>
          </SimBiology>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI20">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-06-10T13:28:42Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </species>
      <species id="PP1_Target1p" name="PP1*Target1p" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="73.6574180095066" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
      <species id="Target1p" name="Target1p" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="377.428073140956" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
      <species id="PKAc_Target1" name="PKAc*Target1" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="36.8287090047503" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
      <species metaid="COPASI21" id="Target1" name="Target1" compartment="mw26af457f_7462_4410_a392_e0bbb6071ea5" initialConcentration="2515.08579984072" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI21">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2017-06-10T13:40:52Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </species>
    </listOfSpecies>
    <listOfParameters>
      <parameter metaid="COPASI22" id="mw5623544e_e7e1_439f_88d3_3b0cbea8ccf5" name="kGaolfGTPase" value="30" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI22">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T11:57:22Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="mw0a87aca4_d8f3_4058_83d0_7addc7e7b981" name="kfPKA*2cAMP" value="0.026" constant="true"/>
      <parameter id="mwf79c6674_0a76_49e2_973d_6677fa109433" name="krPKA*2cAMP" value="350" constant="true"/>
      <parameter id="mw8deeabf3_8313_4e28_90be_ded2d2f045f3" name="krPKAc*PKAr" value="50" constant="true"/>
      <parameter id="mw535609a4_02d1_42d0_ba4b_dce4b2136617" name="kfPKAc*PKAr" value="0.03" constant="true"/>
      <parameter id="mw36eae1b1_84f0_42c3_ad0d_d27aa571346d" name="kfPKA2cAMP*2cAMP" value="0.0346" constant="true"/>
      <parameter id="mwad5ebb51_1d46_40a7_b8d6_13ba4a466b92" name="krPKA2cAMP*2cAMP" value="50" constant="true"/>
      <parameter id="mw0dd72d64_80e1_4f76_a444_fd175dbfab0c" name="kactGolf" value="15" constant="true"/>
      <parameter id="mwa4148cd1_a298_447c_aea8_226688c3f526" name="kcatPDE4*cAMP" value="2.5" constant="true"/>
      <parameter id="mw77fab49b_2ba6_4efe_9342_285f4fd3b7fa" name="kfPDE4*cAMP" value="0.03" constant="true"/>
      <parameter id="mw05f4bef4_5e8d_4a92_bb74_cc0bb4c0260e" name="krPDE4*cAMP" value="1" constant="true"/>
      <parameter id="mw36cb62c6_0b3c_4d1b_9001_3b37aa7477e2" name="krPDE10*cAMP" value="1" constant="true"/>
      <parameter id="mwac1bc66c_2623_47e6_a76d_c1629d962be5" name="kcatPDE10c*cAMP" value="10" constant="true"/>
      <parameter id="mwd1b16e73_4fcb_4e4c_9804_3137259ba749" name="kfPDE10*cAMP" value="1e-006" constant="true"/>
      <parameter id="mw0b1ccae3_37fa_4a23_a817_cd8fc458dc79" name="kfcAMP*PDE10" value="0.1" constant="true"/>
      <parameter id="mw6f753a0e_a7ec_4b4b_bcfc_edb95a3f1296" name="krcAMP*PDE10" value="2" constant="true"/>
      <parameter id="mwf633f298_303f_46d1_b644_ae07ae366f45" name="kcatcAMP*PDE10" value="3" constant="true"/>
      <parameter metaid="COPASI23" id="mw8186cb1d_66c4_4855_bcbb_82d75173ae8a" name="kcatAC5GaolfGTP*ATP" value="50" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI23">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:02:22Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI24" id="mw789c453f_f13d_467f_8f02_d5a714cda15d" name="kicatAC5GaolfGTP*ATP" value="2.55" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI24">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:04:09Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI25" id="mw98b63d59_8744_4e8c_8653_68ae1eb4ad40" name="kcatAC5*ATP" value="1" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI25">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:02:34Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI26" id="mwaa3af366_350e_4f18_936b_6372dc484f82" name="kicatAC5*ATP" value="0.002" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI26">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:04:43Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI27" id="mw9c2302f8_3d47_4247_a338_a02c53fc5331" name="kfAC5*ATP" value="0.0001" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI27">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:05:31Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="mw2f090a45_946b_4587_a3e3_b29f3bb5c6ae" name="kGolfback" value="100" constant="true"/>
      <parameter metaid="COPASI28" id="mw72ceb3da_d538_4f25_8e69_f322eb0b5e57" name="kfAC5GaolfGTP*ATP" value="0.00255" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI28">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:05:12Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI29" id="mw448bd49f_40ad_46c9_81f6_3494057dc37d" name="kfD1R*Golf" value="0.06" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI29">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:04:58Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI30" id="mwa466eec8_9bc0_44d5_8027_d5925b378429" name="krD1R*Golf" value="250" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI30">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:03:00Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI31" id="mwb17941e5_1ad5_42b9_98c6_e62b1a697dbb" name="kfD1RDA*Golf" value="0.06" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI31">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:05:05Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI32" id="mw8e4e88b6_60b3_43bd_8f5c_923712ee64ea" name="krD1RDA*Golf" value="250" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI32">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:03:05Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="mwb494aae2_da19_4ac0_96e2_0dcd9440edc2" name="krAC5X*ATP" value="1" constant="true"/>
      <parameter metaid="COPASI33" id="mw0a255671_d9ca_4384_a153_ce17e1111453" name="kfAC5XGaolfGTP" value="10" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI33">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:03:37Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="mwcd307ee9_33da_4303_9c28_644ad2d1630c" name="krAC5XGaolfGTP" value="1" constant="true"/>
      <parameter id="mw8db06baf_d8bb_4a1a_b415_2d51fa1e53ba" name="krgso" value="1" constant="true"/>
      <parameter id="mw326e0065_b4f6_41ae_b1d0_66092dc5ebb2" name="kfPDE10c*cAMP" value="0.1" constant="true"/>
      <parameter id="mwca52f04a_bb5f_4d3f_ba6d_939bbb3895b9" name="krPDE10c*cAMP" value="2" constant="true"/>
      <parameter id="mwdad9965c_2334_481f_8544_f1a81385a28e" name="kfD1R*DA" value="0.05" constant="true"/>
      <parameter metaid="COPASI34" id="mw3fc2c1ed_0097_4f7f_bcd5_904dc6ad5a56" name="kfD1RGolf*DA" value="0.05" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI34">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:04:51Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI35" id="mwc23d8bf6_2a60_4760_8bf5_c1bab432ab52" name="krD1R*DA" value="250" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI35">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:04:02Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter metaid="COPASI36" id="mw858f28f3_086a_436b_ba23_4fc7372c8884" name="krD1RGolf*DA" value="250" constant="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI36">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T12:03:10Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
      </parameter>
      <parameter id="kfPP1_Target1p" name="kfPP1*Target1p" value="0.001" constant="true"/>
      <parameter id="krPP1_Target1p" name="krPP1*Target1p" value="10" constant="true"/>
      <parameter id="kfPKAc_Target1" name="kfPKAc*Target1" value="0.08" constant="true"/>
      <parameter id="krPKAc_Target1" name="krPKAc*Target1" value="10" constant="true"/>
      <parameter id="kcatPP1_Target1p" name="kcatPP1*Target1p" value="5" constant="true"/>
      <parameter id="kcatPKAc_Target1" name="kcatPKAc*Target1" value="10" constant="true"/>
    </listOfParameters>
    <listOfReactions>
      <reaction metaid="COPASI37" id="revreaction_1" name="revreaction_1" reversible="true">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI37">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2016-03-21T13:20:36Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
        <listOfReactants>
          <speciesReference species="mw0b46978f_b522_4cde_97f0_574cd7dbbae7" stoichiometry="1"/>
          <speciesReference species="mwbe974953_e869_4622_b4a8_745555c8d7fd" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
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