Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)

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Accession:237653
We are investigating how dopaminergic modulation of single channels can be combined to make the D1R possitive MSN more excitable. We also connect multiple channels to substrates of a dopamine induced subcellular cascade to highlight that the classical pathway is too slow to explain DA induced kinetics in the subsecond range (Howe and Dombeck, 2016. doi: 10.1038/nature18942)
Reference:
1 . Lindroos R, Dorst MC, Du K, Filipovic M, Keller D, Ketzef M, Kozlov AK, Kumar A, Lindahl M, Nair AG, Pérez-Fernández J, Grillner S, Silberberg G, Hellgren Kotaleski J (2018) Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2. Front Neural Circuits 12:3 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Channel/Receptor; Dendrite; Molecular Network; Synapse; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia; Striatum;
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum spiny neuron;
Channel(s): I A; I A, slow; I Calcium; I CAN; I K; I K,Ca; I K,leak; I Krp; I Na,t; I Potassium; I R; I T low threshold; Kir;
Gap Junctions:
Receptor(s): D1; Dopaminergic Receptor; AMPA; Gaba; NMDA;
Gene(s):
Transmitter(s): Dopamine; Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Action Potentials; Detailed Neuronal Models; Electrical-chemical; G-protein coupled; Membrane Properties; Neuromodulation; Multiscale; Synaptic noise;
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Du, Kai [kai.du at ki.se]; Keller, Daniel ; Kozlov, Alexander [akozlov at nada.kth.se];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; D1; AMPA; NMDA; Gaba; Dopaminergic Receptor; I Na,t; I T low threshold; I A; I K; I K,leak; I K,Ca; I CAN; I Calcium; I Potassium; I A, slow; I Krp; I R; Kir; Dopamine; Gaba; Glutamate;
{
    "g_pas_all": 	    { "Value": " 1.25e-5 " },
    "gbar_naf_somatic": { "Value": " 9 " },
    "gbar_naf_basal": 	{ "Value": " 0.9 " },
    "gbar_naf_axonal": 	{ "Value": " 9 " },
    "gbar_kaf_somatic": { "Value": " 0.11 ", "Comment": " 0.12 "},
    "gbar_kaf_basal": 	{ "Value": " 0.11 ", "Comment": " 0.12 " },
    "gbar_kas_somatic": { "Value": " 0.012 " },
    "gbar_kas_basal": 	{ "Value": " 0.0012 " },
    "gbar_kas_axonal": 	{ "Value": " 0.007 ", "Comment": " 0.005 "},
    "gbar_kdr_somatic": { "Value": " 0.0007 " },
    "gbar_kdr_basal": 	{ "Value": " 0.0007 " },
    "gbar_kir_somatic": { "Value": " 0.0009 " },
    "gbar_kir_basal": 	{ "Value": " 0.0009 " },
    "gbar_sk_somatic": 	{ "Value": " 0.0000 " },
    "gbar_sk_basal": 	{ "Value": " 0.00002 ", "Comment": " both sk and bk are lower since [Ca]_i is higher in Alex latest version " },
    "gbar_bk_somatic": 	{ "Value": " 0.0001 " },
    "gbar_bk_basal": 	{ "Value": " 0.0001 " }
}

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