Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)

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Accession:237728
" ... Here we show that single presynaptic axons form multiple, spatially clustered inputs onto the distal, but not proximal, dendrites of CA1 pyramidal neurons. These compound connections exhibit ultrastructural features indicative of strong synapses and occur much more commonly in entorhinal than in thalamic afferents. Computational simulations revealed that compound connections depolarize dendrites in a biophysically efficient manner, owing to their inherent spatiotemporal clustering. ..."
Reference:
1 . Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2018) Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites. Nat Neurosci 21:353-363 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell;
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BlossEtAl2018
readme.html
dists.mod *
eff.mod *
gScale.mod
id.mod *
kad.mod *
kap.mod *
kdr.mod *
na3.mod *
nmdaSyn.mod
syns.mod *
addChannels.hoc *
addSpines.hoc
addSynapses.hoc
buildCell.hoc
channelParameters.hoc *
createBiophysics.hoc
createMorphology.hoc
createPlots.hoc
createPointers.hoc
doAnalysis.hoc
getBranchOrder.hoc *
idMorph.hoc
initializationAndRun.hoc
loadMorph.hoc
mosinit.hoc *
processMorph.hoc
proofreadMorph.hoc
resetNSeg.hoc *
screenshot.png
simParameters.hoc
singleSim.hoc
singleSimDist.hoc
spineGeom.hoc
spineShaftConc.hoc
start.hoc
trackVoltages.hoc
twinApical.swc *
varyDistribution.hoc
varySpaceTime.hoc
                            
// CHOOSE FILE NAME
	strdef cellToLoad
	{
		cellToLoad = "twinApical.swc"
	}

// This code is based on the implementation of 
// http://www.neuron.yale.edu/phpbb/viewtopic.php?f=13&t=2272; extended for
// use with an ASCII file emerging from Neurolucida.

	{
		load_file("import3d.hoc")
	}


// This is a dummy template that gets overwritten when the new cell is 
// loaded.  This is included strictly to facilitate the import process.
	begintemplate Cell
	
	public soma, axon, dend, apic
	create soma[1],axon[1],dend[1],apic[1]
	public all,somatic,axonal,basal,apical       
	objref all,somatic,axonal,basal,apical
	
	proc init() {
		all = new SectionList()
		somatic = new SectionList()
		axonal = new SectionList()
		basal = new SectionList()
		apical = new SectionList()
	}
	
	endtemplate Cell



// Load the cell.
// $s1 is the morphology name
// On exit, the return object is a Cell instance with the
// morphology specified by the $s1 file

	obfunc mkcell() { localobj import,morph,cell
		cell = new Cell()
		morph = new Import3d_SWC_read()
		morph.input($s1)
		import = new Import3d_GUI(morph,0)
		execute("forall delete_section()",cell)
		import.instantiate(cell)
		return cell
	}
	
	objref cell
	{
		cell = mkcell(cellToLoad)
	}


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