Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)

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Accession:237728
" ... Here we show that single presynaptic axons form multiple, spatially clustered inputs onto the distal, but not proximal, dendrites of CA1 pyramidal neurons. These compound connections exhibit ultrastructural features indicative of strong synapses and occur much more commonly in entorhinal than in thalamic afferents. Computational simulations revealed that compound connections depolarize dendrites in a biophysically efficient manner, owing to their inherent spatiotemporal clustering. ..."
Reference:
1 . Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2018) Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites. Nat Neurosci 21:353-363 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell;
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BlossEtAl2018
readme.html
dists.mod *
eff.mod *
gScale.mod
id.mod *
kad.mod *
kap.mod *
kdr.mod *
na3.mod *
nmdaSyn.mod
syns.mod *
addChannels.hoc *
addSpines.hoc
addSynapses.hoc
buildCell.hoc
channelParameters.hoc *
createBiophysics.hoc
createMorphology.hoc
createPlots.hoc
createPointers.hoc
doAnalysis.hoc
getBranchOrder.hoc *
idMorph.hoc
initializationAndRun.hoc
loadMorph.hoc
mosinit.hoc *
processMorph.hoc
proofreadMorph.hoc
resetNSeg.hoc *
screenshot.png
simParameters.hoc
singleSim.hoc
singleSimDist.hoc
spineGeom.hoc
spineShaftConc.hoc
start.hoc
trackVoltages.hoc
twinApical.swc *
varyDistribution.hoc
varySpaceTime.hoc
                            
celsius = 35
v_init=-70
global_ra=200.00 	// internal resistivity in ohm-cm 
Cm=1.5 //0.75		// specific membrane capacitance in uF/cm^2 
Cmy=0.075 		// capacitance in myelin 
Rm=40000		// specific membrane resistivity in ohm-cm^2  
Rn=50			// nodal resistivity 
Vleak=-46		// switched from -66, in order to give a proper resting potential
Vrest=-70		// resting potential -60 in control, -66 in Cs+

spinelimit=100      	// distance beyond which to modify for spines 
spinefactor=2.0     	// factor by which to change passive properties 

setgk = .036		// A-type potassium starting density, used in init_bday.hoc
setokslope = 0		// slope of A-type potassium conductance along individual oblique branches. set to 0 in all simulations

gkdr=0.040          	// delayed rectifier density 
gkap=setgk          	// proximal A-type potassium starting density 
gkad=setgk          	// distal A-type potassium  starting density 

dlimit=300	    	// cut-off for increase of A-type density 
dprox=50           	// distance to switch from proximal to distal type 
dslope=0.01         	// slope of A-type density 

okslope = setokslope	// oblique potassium channel gradient 
okmax = .5		// max potassium channel conductance  

ampaWeight = 0.00018 	// in uS; 0.00018 used in Jarsky et al 2005
nmdaWeight = 0.00018	// in uS

gnaSoma = 0.1
gnaSr = 0.03
gnaSlm = 0.03

// Inhibition parameters.
inhRev = -75

npyTau1 = 0.1
npyTau2 = 10
sstTau1 = 0.2 // from Maccaferri et al., 2000
sstTau2 = 18 // from Maccaferri et al., 2000
npyWeight = 0.001 // from Maccaferri et al., 2000
sstWeight = 0.001 // from Maccaferri et al 2000

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