Parallel odor processing by mitral and middle tufted cells in the OB (Cavarretta et al 2016, 2018)

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Accession:240116
"[...] experimental findings suggest that MC and mTC may encode parallel and complementary odor representations. We have analyzed the functional roles of these pathways by using a morphologically and physiologically realistic three-dimensional model to explore the MC and mTC microcircuits in the glomerular layer and deeper plexiform layers. [...]"
References:
1 . Cavarretta F, Burton SD, Igarashi KM, Shepherd GM, Hines ML, Migliore M (2018) Parallel odor processing by mitral and middle tufted cells in the olfactory bulb. Sci Rep 8:7625 [PubMed]
2 . Cavarretta F, Marasco A, Hines ML, Shepherd GM, Migliore M (2016) Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb. Front Comput Neurosci 10:67 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main tufted middle GLU cell; Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; Olfactory bulb (accessory) mitral cell; Olfactory bulb main tufted cell external; Olfactory bulb short axon cell;
Channel(s): I A; I Na,t; I_Ks; I K;
Gap Junctions: Gap junctions;
Receptor(s): AMPA; GabaA; NMDA;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Action Potential Initiation; Active Dendrites; Long-term Synaptic Plasticity; Synaptic Integration; Synchronization; Pattern Recognition; Spatio-temporal Activity Patterns; Temporal Pattern Generation; Sensory coding; Sensory processing; Olfaction;
Implementer(s): Cavarretta, Francesco [francescocavarretta at hotmail.it]; Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main tufted middle GLU cell; Olfactory bulb main interneuron granule TC GABA cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I_Ks; Gaba; Glutamate;
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fi.mod
fi_stdp.mod *
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Gfluct.mod
kamt.mod
kdrmt.mod
ks.mod
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all.py
all2all.py *
assembly.py
balance.py *
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blanes_exc_conn.txt
blanes6.dic
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cfg27.py
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gidfunc.py
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mitral.hoc
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mkmitral.py
modeldata.py
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MTrealSoma2.py
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test_complexity.py
txt2bin.py
util.py *
vrecord.py
weightsave.py
                            
TITLE K slow channel from Wang (2002)
: M.Migliore Dec. 2003

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v (mV)
	celsius		(degC)
	gksbar=.005 (mho/cm2)
	q10=2
	ek

	
	:vhalfp=-34
        vhalfp=-35
	:tp=10
        tp=6	
	:kp=6.5
	kp=2

        :vhalfq =-65
        vhalfq=-50
        kq =6.6
	:to =200
        to=10
	tk =6.85  :6.8
	:a0q=220
        a0q=100

        :tvh=-71.6
        tvh=-50
        

}


NEURON {
	SUFFIX ks
	USEION k READ ek WRITE ik
        RANGE gksbar,gks
        GLOBAL pinf,qinf,taup,tauq
}

STATE {
	p
	q
}

ASSIGNED {
	ik (mA/cm2)
        pinf
        qinf      
        taup
        tauq
        gks
}

INITIAL {
	rates(v)
	p=pinf
	q=qinf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	gks = gksbar*p*q
	ik = gks*(v-ek)

}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rates(v)
        p' = (pinf - p)/taup
        q' = (qinf - q)/tauq
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL qt
        qt=q10^((celsius-25)/10)
        pinf = (1/(1+ exp(-(v-vhalfp)/kp)))
        qinf = (1/(1+ exp((v-vhalfq)/kq)))
	taup = tp/qt
	tauq = to + a0q/(1+exp(-(v-tvh)/tk))/qt
}







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