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Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
 
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Model Information
Model File
Citations
Accession:
243446
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
Reference:
1 .
Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells
Cell Reports
24(6)
:1536-1549
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cerebellum;
Cell Type(s):
Cerebellum Purkinje GABA cell;
Channel(s):
Ca pump;
I K;
I K,Ca;
I Na,p;
I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Action Potential Initiation;
Active Dendrites;
Synaptic Integration;
Dendritic Action Potentials;
Detailed Neuronal Models;
Implementer(s):
Zang, Yunliang ;
Search NeuronDB
for information about:
Cerebellum Purkinje GABA cell
;
I Na,p
;
I K
;
I h
;
I K,Ca
;
Ca pump
;
/
purkinje_pub
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