Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)

 Download zip file 
Help downloading and running models
Accession:243446
"Climbing fibers (CFs) provide instructive signals driving cerebellar learning, but mechanisms causing the variable CF responses in Purkinje cells (PCs) are not fully understood. Using a new experimentally validated PC model, we unveil the ionic mechanisms underlying CF-evoked distinct spike waveforms on different parts of the PC. We demonstrate that voltage can gate both the amplitude and the spatial range of CF-evoked Ca2+ influx by the availability of K+ currents. ... The voltage- and branch-specific CF responses can increase dendritic computational capacity and enable PCs to actively integrate CF signals."
Reference:
1 . Zang Y, Dieudonné S, De Schutter E (2018) Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells Cell Reports 24(6):1536-1549 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje GABA cell;
Channel(s): Ca pump; I K; I K,Ca; I Na,p; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Active Dendrites; Synaptic Integration; Dendritic Action Potentials; Detailed Neuronal Models;
Implementer(s): Zang, Yunliang ;
Search NeuronDB for information about:  Cerebellum Purkinje GABA cell; I Na,p; I K; I h; I K,Ca; Ca pump;
 
/
purkinje_pub
mod
BK_Slow.mod *
CaP.mod *
capmax.mod
CaT.mod *
cdp_AIS.mod *
cdp_smooth.mod *
cdp_soma.mod *
cdp_spiny.mod *
distr.mod
ih.mod *
Kv1.mod
kv3.mod *
kv4f.mod *
kv4s.mod *
mslo.mod *
nap.mod *
narsg.mod
peak.mod *
pkjlk.mod *
SK2.mod *
syn2.mod *
                            
File not selected

<- Select file from this column.
Loading data, please wait...